Bit-mapped somatosensory evoked potentials in Down's syndrome individuals

R. Ferri, S. Del Gracco, M. Elia, S. A. Musumeci, C. Scuderi, P. Bergonzi

Research output: Contribution to journalArticlepeer-review


Middle-latency somatosensory evoked potentials (MLSEPs) were recorded from 19 scalp electrodes in 19 patients with Down's syndrome (DS), in 13 age-matched normal controls and in 11 aged normal individuals. DS patients showed an increase in amplitude of P22, N30, P45, and N60. P100 latency was significantly shortened. After this potential, DS subjects showed the occurrence of a high voltage negative potential at around 100-110 msec followed by another high-voltage positive deflection; both these components showed a frontal-central distribution and were not observed in the two control groups. MLSEPs of DS subjects show peculiar alterations which could be supported by particular neurometabolic and/or neuropathologic changes.

Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalNeurophysiologie Clinique / Clinical Neurophysiology
Issue number5
Publication statusPublished - 1994


  • Down's syndrome
  • middle-latency somatosensory evoked potentials
  • topographic brain mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Bit-mapped somatosensory evoked potentials in Down's syndrome individuals'. Together they form a unique fingerprint.

Cite this