Biventricular pacemaker synchronization: A numerical cardiocirculatory model application to reproduce in vivo data

Arianna Di Molfetta, Claudio De Lazzari, Gianfranco Ferrari, Flavio Moscariello, Giulia Aguzzi, Libera Fresiello, Marek Darowski, Maria Giovanna Trivella, Nicola Alessandri

Research output: Contribution to journalArticle

Abstract

Cardiac Resynchronization Therapy (CRT) seems to be the most encouraging treatment to limit the damages of ventricular remodelling in patients with moderate-severe cardiac insufficiency. Mathematical modelling of the cardiovascular system is a tool potentially useful to understand how the Biventricular Pacemaker (BPM) must be synchronised during CRT. In this work a computer simulator reproduces clinical data measured, on different patients affected by asynchronous ventricular contraction, before and after CRT. Three patients, affected by asynchronous ventricular contraction, were monitored before and after biventricular stimulation through CRT. Measured and simulated data were compared. Results show that the software simulator can well reproduce in vivo data. Besides, simulated results from BPM together with drug therapy are in accordance with literature data. Numerical modelling could be a useful tool to optimize the BPM synchronization.

Original languageEnglish
Pages (from-to)3-15
Number of pages13
JournalBiocybernetics and Biomedical Engineering
Volume30
Issue number1
Publication statusPublished - 2010

Fingerprint

Cardiac resynchronization therapy
Pacemakers
Numerical models
Synchronization
Simulators
Drug therapy
Cardiovascular system

Keywords

  • Circulatory system
  • Computer simulation
  • Coronary circulation
  • Hemodynamics
  • Left ventricle

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Di Molfetta, A., De Lazzari, C., Ferrari, G., Moscariello, F., Aguzzi, G., Fresiello, L., ... Alessandri, N. (2010). Biventricular pacemaker synchronization: A numerical cardiocirculatory model application to reproduce in vivo data. Biocybernetics and Biomedical Engineering, 30(1), 3-15.

Biventricular pacemaker synchronization : A numerical cardiocirculatory model application to reproduce in vivo data. / Di Molfetta, Arianna; De Lazzari, Claudio; Ferrari, Gianfranco; Moscariello, Flavio; Aguzzi, Giulia; Fresiello, Libera; Darowski, Marek; Trivella, Maria Giovanna; Alessandri, Nicola.

In: Biocybernetics and Biomedical Engineering, Vol. 30, No. 1, 2010, p. 3-15.

Research output: Contribution to journalArticle

Di Molfetta, A, De Lazzari, C, Ferrari, G, Moscariello, F, Aguzzi, G, Fresiello, L, Darowski, M, Trivella, MG & Alessandri, N 2010, 'Biventricular pacemaker synchronization: A numerical cardiocirculatory model application to reproduce in vivo data', Biocybernetics and Biomedical Engineering, vol. 30, no. 1, pp. 3-15.
Di Molfetta A, De Lazzari C, Ferrari G, Moscariello F, Aguzzi G, Fresiello L et al. Biventricular pacemaker synchronization: A numerical cardiocirculatory model application to reproduce in vivo data. Biocybernetics and Biomedical Engineering. 2010;30(1):3-15.
Di Molfetta, Arianna ; De Lazzari, Claudio ; Ferrari, Gianfranco ; Moscariello, Flavio ; Aguzzi, Giulia ; Fresiello, Libera ; Darowski, Marek ; Trivella, Maria Giovanna ; Alessandri, Nicola. / Biventricular pacemaker synchronization : A numerical cardiocirculatory model application to reproduce in vivo data. In: Biocybernetics and Biomedical Engineering. 2010 ; Vol. 30, No. 1. pp. 3-15.
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