Biventricular upgrading in patients with conventional pacing system and congestive heart failure: Results and response predictors

Francesco Laurenzi, Augusto Achilli, Andrea Avella, Carlo Peraldo, Serafino Orazi, Giovanni B. Perego, Antonio Cesario, Sergio Valsecchi, Tiziana De Santo, Andrea Puglisi, Claudio Tondo

Research output: Contribution to journalArticlepeer-review


Background: There are few studies on cardiac resynchronization therapy (CRT) in heart failure (HF) patients with preexisting right ventricular (RV) pacing. The purpose of this study was to determine the efficacy of CRT upgrading in RV-paced patients and the predictivity of electromechanical dyssynchrony parameters (EDP) evaluated by standard echocardiography (ECHO) and tissue Doppler imaging (TDI). Methods: Thirty-eight consecutive patients with HF [New York Heart Association (NYHA) class III or IV, LVEF <35], prior continuous RV pacing, and absence of atrial fibrillation were enrolled in the presence of a paced QRS ≥ 150 ms and evaluated by ECHO and TDI. A responder was defined as a patient with a favorable change in NYHA class and neither HF hospitalization nor death, plus an absolute increase of LVEF ≥ 10 units. Results: At six-months follow-up, the whole study population had significant improvement in symptoms, systolic function, and QRS duration (P <0.001); 32 (84%) patients had a favorable clinical outcome, 25 (66%) were considered responders according to the previous definition. Postimplant QRS was similarly reduced in both responders and nonresponders, whereas EDP had a significant improvement only in responders (P <0.05). Using EDP, 23 (79%) patients were responders compared with 2 (22%) patients without mechanical dyssynchrony (P = 0.002). Conclusions: In HF patients with previous RV pacing, CRT is effective to improve clinical, functional outcome, and LV performance and to reduce electromechanical dyssynchrony in a large proportion of patients. Dyssynchrony evaluated by standard and TDI ECHO can be useful for CRT selection of paced patients.

Original languageEnglish
Pages (from-to)1096-1104
Number of pages9
JournalPACE - Pacing and Clinical Electrophysiology
Issue number9
Publication statusPublished - Sep 2007


  • Biventricular upgrading
  • Cardiac resynchronization therapy
  • Heart failure
  • Ventricular dyssynchrony

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Biventricular upgrading in patients with conventional pacing system and congestive heart failure: Results and response predictors'. Together they form a unique fingerprint.

Cite this