BK virus regulatory region sequence deletions in a case of human polyomavirus associated nephropathy (PVAN) after kidney transplantation

Alberta Azzi, Riccardo De Santis, Vittorio Salotti, Niccolò Di Pietro, Fabrizio Ginevri, Patrizia Comoli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The pathogenesis of polyomavirus-associated interstitial nephropathy (PVAN) in kidney transplant recipients is likely to depend upon multiple risk factors, which may include viral characteristics. We report a case of interstitial nephropathy in a young kidney allograft recipient, associated with a BK virus (BKV) strain with a rearranged transcription control region (TCR). BKV strains with deletions and nucleotide substitutions in the TCR were present in a kidney biopsy and urine samples. After retransplantation, following loss of renal function, a BKV strain with an archetypal TCR was detected in association with asymptomatic reactivation.

Original languageEnglish
Pages (from-to)106-108
Number of pages3
JournalJournal of Clinical Virology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2006

Fingerprint

BK Virus
Polyomavirus
Sequence Deletion
Nucleic Acid Regulatory Sequences
Kidney Transplantation
Kidney
Allografts
Nucleotides
Urine
Biopsy

Keywords

  • BKV
  • Kidney transplantation
  • Polyomavirus-associated nephropathy

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

BK virus regulatory region sequence deletions in a case of human polyomavirus associated nephropathy (PVAN) after kidney transplantation. / Azzi, Alberta; De Santis, Riccardo; Salotti, Vittorio; Di Pietro, Niccolò; Ginevri, Fabrizio; Comoli, Patrizia.

In: Journal of Clinical Virology, Vol. 35, No. 1, 01.2006, p. 106-108.

Research output: Contribution to journalArticle

Azzi, Alberta ; De Santis, Riccardo ; Salotti, Vittorio ; Di Pietro, Niccolò ; Ginevri, Fabrizio ; Comoli, Patrizia. / BK virus regulatory region sequence deletions in a case of human polyomavirus associated nephropathy (PVAN) after kidney transplantation. In: Journal of Clinical Virology. 2006 ; Vol. 35, No. 1. pp. 106-108.
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