BKV infection and hemorrhagic cystitis after allogeneic bone marrow transplant

D. Fioriti, A. M. Degener, M. Mischitelli, M. Videtta, A. Arancio, S. Sica, F. Sorà, Valeria Pietropaolo

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Hemorrhagic cystitis (HC) is a well-known complication after allogeneic bone marrow transplant (BMT) and can be related to adenovirus or human polyomavirus BK (BKV) infections. In this study a group of 20 patients after allogeneic BMT has been examined. BMT urine samples were analysed for the presence of Adenovirus and BKV DNA by means of polymerase chain reaction (PCR). 5/20 BMT patients developed HC after BMT. The presence of BKV DNA in urine samples was evident in 3/15 patients without HC and in 5/5 patients with HC. In 2/5 HC-patients the BKV DNA was not found after therapy with Cidofovir and Ribavirin. The search for adenovirus DNA in all samples was negative. The analysis of BKV non-coding control region (NCCR) isolated from urine samples revealed a structure very similar to the archetype in all samples. The RFLP (Restriction Fragment Length Polymorphism assay) showed the presence of BKV subtypes I and IV, with the prevalence of subtype I (4/5). This study supports the hypothesis that HC is mainly related to BKV rather than to adenovirus infection in BMT patients. Moreover, since BKV subtype I was predominant, it is reasonable to hypothesize that a specific BKV subtype could be associated with the development of HC.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalInternational Journal of Immunopathology and Pharmacology
Issue number2
Publication statusPublished - Apr 2005


  • Adenovirus
  • BKV
  • Hemorrhagic cystitis
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Pharmacology


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