Bladder cancer in pediatric patients

Santiago Vallasciani, Giacinto Marrocco, Caterina Gulia, Andrea Zangari, Roberto Piergentili

Research output: Contribution to journalArticle


Lower urinary tract malignancies are very rare in pediatric age and highly uncommon in the first two decades of life; indeed, according to most available reports, their incidence among all affected patients if far lower that 1%. In fact, the sum of all patients for all bladder tumours in available scientific literature is just a few hundreds. These pathologies resemble in some instances their adult counterparts, such as painless macroscopic haematuria as the first symptom, the males are more affected than females, the familiarity, the relationship with specific chemicals such as those linked to pollution. Nonetheless, there are other aspects of bladder cancers (BC) in children that show specific characteristics: (i) pediatric BC are usually unifocal; (ii) despite delayed diagnosis due to the unexpected pathology, consequently driving towards a different initial diagnosis, children usually show lower grade and stage cancers at presentation, compared to adults; (iii) their prognosis is, in general, relatively good compared to that of elder people; (iv) the recurrence rate is very low; (v) the tumors usually show an indolent behavior; (vi) although males are more affected, the male-to-female ratio shows an agedependent value, with males being more affected at younger ages. Taken together, these facts suggest that BC in young patients is different from that of elderly people. Moreover, also its treatment needs a different approach, since in children and adolescents it is very important to preserve fertility and sexual performances. In this report, similarities and differences in BC between young and adults will be discussed, and alternative therapeutic approaches will be illustrated.

Original languageEnglish
Pages (from-to)111-128
Number of pages18
JournalInternational Journal of Cancer Research and Prevention
Issue number2
Publication statusPublished - 2014


ASJC Scopus subject areas

  • Oncology
  • Social Psychology

Cite this

Vallasciani, S., Marrocco, G., Gulia, C., Zangari, A., & Piergentili, R. (2014). Bladder cancer in pediatric patients. International Journal of Cancer Research and Prevention, 7(2), 111-128.