Bladder filling inhibits somatic spinal motoneurones

M. Inghilleri, A. Carbone, F. Pedace, A. Conte, V. Frasca, A. Berardelli, G. Cruccu, M. Manfredi

Research output: Contribution to journalArticle

Abstract

Objectives: Despite evidence that the activation of visceral afferents modulates spinal motoneurone activity in humans the responsible circuits remain unclear. We investigated changes in spinal motoneurone excitability during bladder filling in 8 healthy subjects and in 8 patients with spinal cord lesions and 5 patients with multi-infarct encephalopathy. Methods: Spinal motoneurone excitability was studied by analysing changes in H-reflex, F-wave and motor-evoked potential (MEP) size recorded from the calf muscles under different bladder filling conditions. Results: In normal subjects, maximal bladder filling significantly suppressed the H-reflex, F-wave and MEPs; after bladder voiding these responses returned to normal. In patients with encephalopathy maximal bladder filling strongly reduced H-reflex size; similarly to normal subjects H-reflex returned to control value after bladder voiding. In patients with spinal cord lesions, activation of bladder afferents left the H-reflex unchanged. Conclusions: These findings indicate that bladder distension induces post-synaptic inhibition of spinal motoneurones through a suprasegmental pathway, which is interrupted by rostral spinal cord lesions. This vesical-induced inhibition is probably mediated by the propriospinal system rather than by the diffuse noxious inhibitory control circuit.

Original languageEnglish
Pages (from-to)2255-2260
Number of pages6
JournalClinical Neurophysiology
Volume112
Issue number12
DOIs
Publication statusPublished - 2001

Keywords

  • Bladder proprioception
  • H-reflex
  • Motoneurone excitability
  • Motor-evoked potential

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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  • Cite this

    Inghilleri, M., Carbone, A., Pedace, F., Conte, A., Frasca, V., Berardelli, A., Cruccu, G., & Manfredi, M. (2001). Bladder filling inhibits somatic spinal motoneurones. Clinical Neurophysiology, 112(12), 2255-2260. https://doi.org/10.1016/S1388-2457(01)00674-5