Bladder metastases of appendiceal mucinous adenocarcinoma: A case presentation

Gianluigi Taverna, Matteo Corinti, Piergiuseppe Colombo, Fabio Grizzi, Mauro Severo, Alessando Piccinelli, Guido Giusti, Alessio Benetti, Paolo A. Zucali, Pierpaolo Graziotti

Research output: Contribution to journalArticlepeer-review


Background: Appendiceal adenocarcinoma is rare with a frequency of 0.08% of all surgically removed appendices. Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.Case Presentation: A case is reported of a 45-years old woman with mucinous cystadenocarcinoma of the appendix with bladder metastasis. Although ultrasonography and voided urinary cytology were negative, abdomen computed tomography (CT) scan and cystoscopy and subsequent pathological examination revealed a mass exclusively located in the anterior wall of the bladder. Histopathology of the transurethral bladder resection revealed a bladder adenocarcinoma [6 cm (at the maximum diameter) × 2,5 cm; approximate weight: 10 gr] with focal mucinous aspects penetrating the muscle and perivisceral fat. Laparotomy evidenced the presence of a solid mass of the appendix (2,5 cm × 3 cm × 2 cm) extending to the loco-regional lymph nodes. Appendectomy and right hemicolectomy, linfoadenectomy and partial cystectomy were performed. The subsequent pathological examination revealed a mucinous cystadenocarcinoma of the appendix with metastatic cells colonising the anterior bladder wall and several colic lymph nodes.Conclusions: The rarity of the appendiceal carcinoma invading the urinary bladder and its usual involvement of nearest organs and the posterior bladder wall, led us to describe this case which demonstrates the ability of the appendiceal cancer to metastasize different regions of urinary bladder.

Original languageEnglish
Article number62
JournalBMC Cancer
Publication statusPublished - Feb 23 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics


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