Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 729-737 |
| Number of pages | 9 |
| Journal | Haematologica |
| Volume | 104 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- azacitidine
- decitabine
- romidepsin
- transcriptome
- adult
- animal experiment
- animal model
- animal tissue
- Article
- CAL-1 [Human melanoma] cell line
- chromatin immunoprecipitation
- clinical article
- controlled study
- dendritic cell sarcoma
- epigenetics
- female
- gene mutation
- hematopoietic stem cell transplantation
- histone methylation
- human
- immune dysregulation
- immunohistochemistry
- male
- middle aged
- mouse
- nonhuman
- plasmacytoid dendritic cell
- protein expression
- RNA sequence
- Sanger sequencing
- single nucleotide polymorphism
- somatic mutation
- upregulation
- whole exome sequencing
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Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target. / Sapienza, M.R.; Abate, F.; Melle, F. et al.
In: Haematologica, Vol. 104, No. 4, 2019, p. 729-737.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target
AU - Sapienza, M.R.
AU - Abate, F.
AU - Melle, F.
AU - Orecchioni, S.
AU - Fuligni, F.
AU - Etebari, M.
AU - Tabanelli, V.
AU - Laginestra, M.A.
AU - Pileri, A.
AU - Motta, G.
AU - Rossi, M.
AU - Agostinelli, C.
AU - Sabattini, E.
AU - Pimpinelli, N.
AU - Truni, M.
AU - Falini, B.
AU - Cerroni, L.
AU - Talarico, G.
AU - Piccioni, R.
AU - Amente, S.
AU - Indio, V.
AU - Tarantino, G.
AU - Brundu, F.
AU - Paulli, M.
AU - Berti, E.
AU - Facchetti, F.
AU - Dellino, G.I.
AU - Bertolini, F.
AU - Tripodo, C.
AU - Rabadan, R.
AU - Pileri, S.A.
N1 - Cited By :5 Export Date: 2 March 2020 CODEN: HAEMA Correspondence Address: Sapienza, M.R.; Hematopathology Unit, Department of Experimental, Diagnostic, and Specialty Medicine, S. Orsola-Malpighi Hospital, University of BolognaItaly; email: mariarosaria.sapienza@gmail.com Chemicals/CAS: azacitidine, 320-67-2, 52934-49-3; decitabine, 2353-33-5; romidepsin, 128517-07-7 Funding details: Hospital for Sick Children Funding details: Università di Bologna Funding details: Università degli Studi di Brescia Funding details: Fondazione IRCCS Policlinico San Matteo Funding details: Università degli Studi di Napoli Federico II Funding details: Royal College of Physicians and Surgeons of Canada Funding details: Department of Surgery Funding details: Associazione Italiana per la Ricerca sul Cancro, 5x1000 10007, IG 15762 Funding text 1: 1Hematopathology Unit, Department of Experimental, Diagnostic, and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Italy; 2Department of Systems Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA; 3Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, NY, USA; 4Division of Haematopathology, European Institute of Oncology, Milan, Italy; 5Laboratory of Hematology-Oncology, European Institute of Oncology, Milan, Italy; 6Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada: 7Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy; 8Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Italy; 9Pathological Anatomy Histology & Cytogenetics, Niguarda Cancer Center, Niguarda-Ca' Granda Hospital, Milan, Italy; 10Institute of Hematology and Center for Hemato-Oncology Research (CREO), University and Hospital of Perugia, Italy; 11Universitätsklinik für Dermatologie und Venerologie, LKH-Universitatsklinikum Graz, Austria; 12Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; 13Department of Molecular Medicine and Medical Biotechnologies, University of Naples ‘Federico II’, Italy; 14"Giorgio Prodi" Cancer Research Center, University of Bologna, Italy; 15Unit of Anatomic Pathology, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Policlinic, Pavia, Italy; 16Department of Dermatology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinic and Milan University, Milan, Italy; 17Pathology Section, Department of Molecular and Translational Medicine, University of Brescia, Italy; 18Department of Oncology and Hemato-Oncology, University of Milan, Italy and19Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo School of Medicine, Italy Funding text 2: The present work was supported by the AIRC grants IG 15762 and 5x1000 10007 “Genetics-driven targeted management of lymphoid malignancies” and the Grant “Innovative approaches to the diagnosis and pharmacogenetic-based therapies of primary hepatic tumours, peripheral B and T-cell lymphomas and lymphoblastic leukaemias” Strategic Programme 2010-2012 Regione Emilia Romagna - Università (all to SAP). 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PY - 2019
Y1 - 2019
N2 - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy. In order to identify genetic alterations useful for a new treatment design, we used whole-exome sequencing to analyze 14 BPDCN patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program to be the most significantly undermined (P
AB - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy. In order to identify genetic alterations useful for a new treatment design, we used whole-exome sequencing to analyze 14 BPDCN patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program to be the most significantly undermined (P
KW - azacitidine
KW - decitabine
KW - romidepsin
KW - transcriptome
KW - adult
KW - animal experiment
KW - animal model
KW - animal tissue
KW - Article
KW - CAL-1 [Human melanoma] cell line
KW - chromatin immunoprecipitation
KW - clinical article
KW - controlled study
KW - dendritic cell sarcoma
KW - epigenetics
KW - female
KW - gene mutation
KW - hematopoietic stem cell transplantation
KW - histone methylation
KW - human
KW - immune dysregulation
KW - immunohistochemistry
KW - male
KW - middle aged
KW - mouse
KW - nonhuman
KW - plasmacytoid dendritic cell
KW - protein expression
KW - RNA sequence
KW - Sanger sequencing
KW - single nucleotide polymorphism
KW - somatic mutation
KW - upregulation
KW - whole exome sequencing
U2 - 10.3324/haematol.2018.202093
DO - 10.3324/haematol.2018.202093
M3 - Article
VL - 104
SP - 729
EP - 737
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 4
ER -