Bleeding and thrombosis in 55 patients with inherited afibrinogenaemia

M. Lak, M. Keihani, F. Elahi, F. Peyvandi, P. M. Mannucci

Research output: Contribution to journalArticlepeer-review

Abstract

Knowledge of the spectrum of symptoms in patients with inherited afibrinogenaemia is limited by the rarity of this coagulation defect. We compared a large series of 55 afibrinogenaemic patients from Iran with 100 patients with severe factor VIII deficiency. In afibrinogenaemia there was a higher frequency of mucosal-type bleeding symptoms but joint and muscle bleeding was less frequent and severe than in haemophilia. Umbilical cord bleeding was relatively frequent only in afibrinogenaemic patients. Two young patients developed spontaneous thrombotic episodes and three women had recurrent abortions. Overall, in afibrinogenaemia bleeding symptoms are qualitatively different and less severe than in haemophilia. Afibrinogenaemia can also be accompanied by thrombotic manifestations.

Original languageEnglish
Pages (from-to)204-206
Number of pages3
JournalBritish Journal of Haematology
Volume107
Issue number1
DOIs
Publication statusPublished - 1999

Keywords

  • Afibrinogenaemia
  • Haemophilia
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

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