Bleeding in renal failure: A possible role of vascular prostacyclin (PGI 2)

G. Remuzzi, D. Marchesi, A. E. Cavenaghi, M. Livio, M. B. Donati, G. de Gaetano, G. Mecca

Research output: Contribution to journalArticlepeer-review


Specimens of venous tissues from a group of 25 patients with chronic uremia and 7 patients with acute renal failure generated significantly higher PGI 2-like (platelet aggregation inhibiting) activity than venous tissues from 30 normal subjects. After repeated washings, when this activity could barely be detected in the controls, pronounced inhibitory activity was still evident in samples containing venous tissues from uremic patients. Both prolonged bleeding times and increased PGI 2-like activity returned to normal in 4 acute uremic patients on restoration of their renal function. These findings may be relevant to the pathogenesis of bleeding in renal failure.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalClinical Nephrology
Issue number3
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Bleeding in renal failure: A possible role of vascular prostacyclin (PGI <sub>2</sub>)'. Together they form a unique fingerprint.

Cite this