A 'template', semiauthomatic device, recently developed for measuring bleeding time in man, has been reliably applied to evaluate the bleeding time in rats. This technique allows repeated measurements on the same animal. Following oral or intraperitoneal administration of acetylsalicylic acid (at various dosages), no significant variations of bleeding time were observed, although collagen-and Thrombofax - induced platelet aggregation, measured ex vivo in the aggregometer, was strongly inhibited. These results suggest that platelets might not play a fundamental role in the primary haemostasis of rat, as challenged by the bleeding time technique used in this study.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine