Bleomycin-induced chromosome aberrations in lymphocytes derived from patients with lamellar ichthyosis

Patrizia Vernole, Angela Tullio, Daniela Caporossi, Biagio Didona, Gerry Melino, Bruna Tedeschi

Research output: Contribution to journalArticle

Abstract

Patients affected by some genetic skin defects, for example, dyskeratosis congenita or scleroderma, may present spontaneous or induced chromosomal fragility. Hence we performed a cytogenetic analysis in families of patients affected by lamellar ichthyosis, an autosomal recessive disease not yet fully characterized at the cellular and molecular levels. Chromosomal fragility was assayed in untreated lymphocyte cultures and in those supplemented with aphidicolin or bleomycin. Cells from some affected patients and some of their parents showed hypersensitivity to the radiomimetic agent bleomycin.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume108
Issue number2
DOIs
Publication statusPublished - Jan 15 1999

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Fingerprint Dive into the research topics of 'Bleomycin-induced chromosome aberrations in lymphocytes derived from patients with lamellar ichthyosis'. Together they form a unique fingerprint.

  • Cite this