Abstract
We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 422-424 |
| Number of pages | 3 |
| Journal | Clinical Rheumatology |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Bleomycin
- Connective tissue disease
- HLA
- Scleroderma
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Bleomycin-induced scleroderma : Report of a case with a chronic course rather than the typical acute/subacute self-limiting form. / Passiu, G.; Cauli, A.; Atzeni, F.; Aledda, M.; Dessole, G.; Sanna, G.; Nurchis, P.; Vacca, A.; Garau, P.; Laudadio, M.; Mathieu, A.
In: Clinical Rheumatology, Vol. 18, No. 5, 1999, p. 422-424.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bleomycin-induced scleroderma
T2 - Report of a case with a chronic course rather than the typical acute/subacute self-limiting form
AU - Passiu, G.
AU - Cauli, A.
AU - Atzeni, F.
AU - Aledda, M.
AU - Dessole, G.
AU - Sanna, G.
AU - Nurchis, P.
AU - Vacca, A.
AU - Garau, P.
AU - Laudadio, M.
AU - Mathieu, A.
PY - 1999
Y1 - 1999
N2 - We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.
AB - We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.
KW - Bleomycin
KW - Connective tissue disease
KW - HLA
KW - Scleroderma
UR - http://www.scopus.com/inward/record.url?scp=0032860658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032860658&partnerID=8YFLogxK
U2 - 10.1007/s100670050131
DO - 10.1007/s100670050131
M3 - Article
C2 - 10524560
AN - SCOPUS:0032860658
VL - 18
SP - 422
EP - 424
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 5
ER -