Bleomycin-induced scleroderma: Report of a case with a chronic course rather than the typical acute/subacute self-limiting form

G. Passiu; A. Cauli; F. Atzeni; M. Aledda; G. Dessole; G. Sanna; P. Nurchis; A. Vacca; P. Garau; M. Laudadio; A. Mathieu

doi:10.1007/s100670050131

Bleomycin-induced scleroderma: Report of a case with a chronic course rather than the typical acute/subacute self-limiting form

G. Passiu, A. Cauli, F. Atzeni, M. Aledda, G. Dessole, G. Sanna, P. Nurchis, A. Vacca, P. Garau, M. Laudadio, A. Mathieu

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.

Original language	English
Pages (from-to)	422-424
Number of pages	3
Journal	Clinical Rheumatology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/s100670050131
Publication status	Published - 1999

Keywords

Bleomycin
Connective tissue disease
HLA
Scleroderma

ASJC Scopus subject areas

Rheumatology
Immunology

Access to Document

10.1007/s100670050131

Cite this

Bleomycin-induced scleroderma : Report of a case with a chronic course rather than the typical acute/subacute self-limiting form. / Passiu, G.; Cauli, A.; Atzeni, F.; Aledda, M.; Dessole, G.; Sanna, G.; Nurchis, P.; Vacca, A.; Garau, P.; Laudadio, M.; Mathieu, A.

In: Clinical Rheumatology, Vol. 18, No. 5, 1999, p. 422-424.

Research output: Contribution to journal › Article › peer-review

@article{aa68929ecc0a4013b79574e612ff6d55,

title = "Bleomycin-induced scleroderma: Report of a case with a chronic course rather than the typical acute/subacute self-limiting form",

abstract = "We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.",

keywords = "Bleomycin, Connective tissue disease, HLA, Scleroderma",

author = "G. Passiu and A. Cauli and F. Atzeni and M. Aledda and G. Dessole and G. Sanna and P. Nurchis and A. Vacca and P. Garau and M. Laudadio and A. Mathieu",

year = "1999",

doi = "10.1007/s100670050131",

language = "English",

volume = "18",

pages = "422--424",

journal = "Clinical Rheumatology",

issn = "0770-3198",

publisher = "Springer London",

number = "5",

}

TY - JOUR

T1 - Bleomycin-induced scleroderma

T2 - Report of a case with a chronic course rather than the typical acute/subacute self-limiting form

AU - Passiu, G.

AU - Cauli, A.

AU - Atzeni, F.

AU - Aledda, M.

AU - Dessole, G.

AU - Sanna, G.

AU - Nurchis, P.

AU - Vacca, A.

AU - Garau, P.

AU - Laudadio, M.

AU - Mathieu, A.

PY - 1999

Y1 - 1999

N2 - We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.

AB - We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.

KW - Bleomycin

KW - Connective tissue disease

KW - HLA

KW - Scleroderma

UR - http://www.scopus.com/inward/record.url?scp=0032860658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032860658&partnerID=8YFLogxK

U2 - 10.1007/s100670050131

DO - 10.1007/s100670050131

M3 - Article

C2 - 10524560

AN - SCOPUS:0032860658

VL - 18

SP - 422

EP - 424

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 5

ER -

Bleomycin-induced scleroderma: Report of a case with a chronic course rather than the typical acute/subacute self-limiting form

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this