Abstract
We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.
Original language | English |
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Pages (from-to) | 422-424 |
Number of pages | 3 |
Journal | Clinical Rheumatology |
Volume | 18 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1999 |
Keywords
- Bleomycin
- Connective tissue disease
- HLA
- Scleroderma
ASJC Scopus subject areas
- Rheumatology
- Immunology