Blindness and glaucoma: A multicenter data review from 7 academic eye clinics

Luca Rossetti, Maurizio Digiuni, Montesano Giovanni, Marco Centofanti, Antonio M. Fea, Michele Iester, Paolo Frezzotti, Michele Figus, Antonio Ferreras, Francesco Oddone, Lucia Tanga, Teresa Rolle, Valentina Battaglino, Chiara Posarelli, Ilaria Motolese, Pietro Mittica, Simone Alex Bagaglia, Cristina Menicacci, Stefano De Cilla', Alessandro AutelitanoPaolo Fogagnolo

Research output: Contribution to journalArticlepeer-review


Purpose To evaluate frequency, conversion rate, and risk factors for blindness in glaucoma patients treated in European Universities. Methods This multicenter retrospective study included 2402 consecutive patients with glaucoma in at least one eye. Medical charts were inspected and patients were divided into those blind and the remainder ('controls'). Blindness was defined as visual acuity-0.05 and/or visual field loss to less than 10°. Results Unilateral and bilateral blindness were respectively 11.0% and 1.6%at the beginning, and 15.5%and 3.6% at the end of the observation period (7.5±5.5 years, range:1-25 years); conversion to blindness (at least unilateral) was 1.1%/year. 134 eyes (97 patients) developed blindness by POAG during the study. At the first access to study centre, they had mean deviation (MD) of -17.1±8.3 dB and treated intraocular pressure (IOP) of 17.1±6.6 mmHg. During follow-up the IOP decreased by 14%in these eyes but MD deteriorated by 1.1±3.5 dB/year, which was 5-fold higher than controls (0.2±1.6 dB/year). In a multivariate model, the best predictors for blindness by glaucoma were initial MD (p

Original languageEnglish
Article numbere0136632
JournalPLoS One
Issue number8
Publication statusPublished - Aug 24 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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