Blink reflex changes in parkinsonism following severe traumatic brain injury correlates with diffuse axonal injury

Rita Formisano, Paola Cicinelli, Maria Gabriella Buzzi, Stefano Brunelli, Ross Zafonte, Vincenzo Vinicola, Andrea Gabrielli, Umberto Sabatini

Research output: Contribution to journalArticle

Abstract

Survivors of severe traumatic brain injury (TBI) may show transient or persistent extrapyramidal symptoms such as rigidity, akinesia and parkinsonian posture, associated with hypomimia, notestinguishable glabellar tap reflex, seborrhea and hypersalivation. The Blink Reflex (BR), an electrically-induced reflex, is abnormal in Parkinson's disease (PD) and in some parkinsonisms. The aim of the study was to investigate BR habituation and its recovery cycle in survivors of severe TBI suffering from parkinsonian syndrome and the possible correlation with neuroimaging findings. Twenty-three patients (18 males, 5 females; mean age 23.7 years, range 13-35), who sustained a severe TBI, (Glasgow Coma Scale or GCS, lower than 8 in the first 48 hours), and followed by coma for a duration equal or longer than 15 days, were studied during the post-acute or chronic phase. Enrollement criteria include the presence of at least 3 extrapyramidal symptoms. BR was elicited by electrical stimulation of the supraorbital nerve and responses were recorded with surface electrodes from the orbicularis oculi muscle ipsilateral to the stimulation. A repeated series of 10 electrical stimuli was applied at the frequencies of stimulation of 0.3, 0.5, 0.7, 1.0, 1.5, 2.0 and 3.0 Hz, respectively. Values between 0.5 and 1 Hz were considered as normal, according to the international literature, Cerebral Magnetic Resonance (C-MRI), with fast sequences was performed within 3 months after brain injury. Ten healthy subjects, age and sex matched, served as controls and underwent the same procedure. Nineteen of the twenty-three patients (82.6%) showed a significantly reduced BR habituation in comparison with controls. This findings highly correlated with C-MRI diagnosis of Diffuse Axonal Injury (DAI). A normal BR habituation was found in only 4 out of 23 patients (17%). In these subjects, C-MRI revealed focal lesions rather than DAI. BR changes correlate with parkinsonian signs and neuroimaging findings. BR may have a role as a diagnostic tool in post-traumatic parkinsonism and as a prognostic tool to evaluate the effect of therapeutic options.

Original languageEnglish
JournalMedical Science Monitor
Volume15
Issue number3
Publication statusPublished - Mar 2009

Fingerprint

Diffuse Axonal Injury
Blinking
Parkinsonian Disorders
Neuroimaging
Survivors
Sialorrhea
Seborrheic Dermatitis
Abnormal Reflexes
Glasgow Coma Scale
Therapeutic Uses
Coma
Traumatic Brain Injury
Posture
Brain Injuries
Electric Stimulation
Parkinson Disease
Reflex
Healthy Volunteers
Electrodes
Magnetic Resonance Spectroscopy

Keywords

  • Blink reflex habituation
  • Coma
  • Diffuse axonal injury
  • Post-traumatic parkinsonism
  • Severe traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Blink reflex changes in parkinsonism following severe traumatic brain injury correlates with diffuse axonal injury. / Formisano, Rita; Cicinelli, Paola; Buzzi, Maria Gabriella; Brunelli, Stefano; Zafonte, Ross; Vinicola, Vincenzo; Gabrielli, Andrea; Sabatini, Umberto.

In: Medical Science Monitor, Vol. 15, No. 3, 03.2009.

Research output: Contribution to journalArticle

Formisano, R, Cicinelli, P, Buzzi, MG, Brunelli, S, Zafonte, R, Vinicola, V, Gabrielli, A & Sabatini, U 2009, 'Blink reflex changes in parkinsonism following severe traumatic brain injury correlates with diffuse axonal injury', Medical Science Monitor, vol. 15, no. 3.
Formisano, Rita ; Cicinelli, Paola ; Buzzi, Maria Gabriella ; Brunelli, Stefano ; Zafonte, Ross ; Vinicola, Vincenzo ; Gabrielli, Andrea ; Sabatini, Umberto. / Blink reflex changes in parkinsonism following severe traumatic brain injury correlates with diffuse axonal injury. In: Medical Science Monitor. 2009 ; Vol. 15, No. 3.
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AU - Zafonte, Ross

AU - Vinicola, Vincenzo

AU - Gabrielli, Andrea

AU - Sabatini, Umberto

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