Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus

Alberto Bacci, Giulio Sancini, Claudia Verderio, Simona Armano, Elena Pravettoni, Riccardo Fesce, Silvana Franceschetti, Michela Matteoli

Research output: Contribution to journalArticlepeer-review

Abstract

Recurrent epileptiform activity occurs spontaneously in cultured CNS neurons and in brain slices in which GABA inhibition has been blocked. We demonstrate here that pharmacological treatments resulting in either the block of glutamine production by astrocytes or the inhibition of glutamine uptake by neurons suppress or markedly decrease the frequency of spontaneous epileptiform discharges both in primary hippocampal cultures and in disinhibited hippocampal slices. These data point to an important role for the neuron-astrocyte metabolic interaction in sustaining episodes of intense rhythmic activity in the CNS, and thereby reveal a new potential target for antiepileptic treatments.

Original languageEnglish
Pages (from-to)2302-2310
Number of pages9
JournalJournal of Neurophysiology
Volume88
Issue number5
Publication statusPublished - Nov 1 2002

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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