Riduzione del danno vascolare in un modello sperimentale di rigetto cronico mediante blocco selettivo della via di costimolazione B7: CD28

Translated title of the contribution: Blockade of B7: CD28 costimulatory pathway reduces the vascular damage in an experimental model of chronic rejection

J. Rademacher, L. Cansolino, E. Lillo, G. Oldani, A. Delfino, C. Matteotti, A. Gaspari, M. Maestri, P. Dionigi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. Costimulatory blockade and donor specific transfusion (DST) can catalyze tolerance of transplanted organs through a multistep adaptation between the recipient and donor immune systems. Such an in vivo process may prolong graft survival. Aim of this study was to evaluate the outcome of aortic transplantation under CTLA4Ig and DST in a mismatched model in rats. Methods. Orthotopic aortic transplantation was performed in recipients Lewis from Wistar-Furth rats. The animals were stratified into 3 groups, according to the postoperative treatment. Group 1 had aortic transplantation only (controls, n=6), while group 2 (n=7) had a load of donor splenocytes (DST). Group 3 was treated with DST and CTLA4Ig. All the animals were sacrificed at the 60 th postoperative day and the aortic specimens were prepared for histology. Intimal cells, muscular cells and lymphocyte cell infiltration were evaluated by serial counts. Results. In Group 1 there was a severe chronic rejection, while group 2 showed a slower onset of chronic rejection with less inflammatory infiltrate than group 1 (P

Translated title of the contributionBlockade of B7: CD28 costimulatory pathway reduces the vascular damage in an experimental model of chronic rejection
Original languageItalian
Pages (from-to)487-496
Number of pages10
JournalMinerva Chirurgica
Volume60
Issue number6
Publication statusPublished - Dec 2005

ASJC Scopus subject areas

  • Surgery

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