Blockade of the diazepam-induced increase in rat striatal acetylcholine content by the specific benzodiazepine antagonists ethyl-β-carboline-3-carboxylate and Ro 15-1788

Krystyna Kolasa, Silvana Consolo, Gianluigi Forloni, Silvio Garattini, Herbert Ladinsky

Research output: Contribution to journalArticlepeer-review

Abstract

Diazepam increased the acetylcholine content in the striatum and the hippocampus of the rat. This effect was antagonized in both brain areas by treatment with the specific central benzodiazepine blockers ethyl-β-carboline-3-carboxylate and Ro 15-1788, whereas the peripheral antagonist Ro 5-4864 was ineffective. Pretreatment with picrotoxin, a known GABA antagonist did not interface with the diazepam-induced acetylcholine increase. These results indicate a specific involvement of benzodiazepine receptors in the cholinergic action of diazepam and this effect appears to be independent of GABA receptor activation.

Original languageEnglish
Pages (from-to)342-345
Number of pages4
JournalBrain Research
Volume336
Issue number2
DOIs
Publication statusPublished - Jun 17 1985

Keywords

  • acetylcholine
  • benzodiazepine antagonists
  • diazepam
  • GABA
  • hippocampus
  • striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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