Blood and urine inducible protein 10 as potential markers of disease activity

L. Petrone, A. Cannas, V. Vanini, G. Cuzzi, F. Aloi, M. Nsubuga, J. Sserunkuma, R. A. Nazziwa, L. Jugheli, T. Lukindo, E. Girardi, A. Antinori, L. Pucci, K. Reither, D. Goletti

Research output: Contribution to journalArticlepeer-review

Abstract

SETTING: Blood interferon-γ inducible protein 10 (IP-10) has been proposed as a biomarker of disease activity for both tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Urine IP-10 has been detected in adults with active TB, and its level decreases after successful anti-tuberculosis treatment. OBJECTIVE: To evaluate blood and urine IP-10 as biomarker of disease activity. DESIGN: Patients with HIV-TB and active TB were enrolled. Individuals with HIV infection only and healthy donors were included as controls. Blood and urine IP-10 levels were measured using an enzyme-linked immunosorbent assay. RESULTS: Of 39 active TB patients enrolled, 24 were HIV-infected and 15 were HIV-uninfected. Of 87 control subjects without active TB, 54 were HIV-infected and 33 were HIV-uninfected. IP-10 analysis was performed in patients with concomitant blood and urine sample collection. Blood IP-10 was associated with active TB, regardless of HIV infection status; urine IP-10 levels were increased in active TB patients, although the difference was significant in HIV-infected individuals only. Finally, in HIV-infected patients, both blood and urine IP-10 levels were inversely correlated with CD4 Tcell counts. CONCLUSION: These findings suggest that IP-10 could be used as a biomarker for disease activity (inflammation).

Original languageEnglish
Pages (from-to)1554-1561
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume20
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • Biomarkers
  • HIV
  • Inflammation
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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