Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Aristotelis Chatziioannou, Panagiotis Georgiadis, Dennie G. Hebels, Irene Liampa, Ioannis Valavanis, Ingvar A. Bergdahl, Anders Johansson, Domenico Palli, Marc Chadeau-Hyam, Alexandros P. Siskos, Hector Keun, Maria Botsivali, Theo M.C.M. De Kok, Almudena Espín Pérez, Jos C.S. Kleinjans, Paolo Vineis, Soterios A. Kyrtopoulos, Ralph Gottschalk, Danitsja Van Leeuwen, Leen Timmermans & 30 others Benedetta Bendinelli, Rachel Kelly, Roel Vermeulen, Lutzen Portengen, Fatemeh Saberi-Hosnijeh, Beatrice Melin, Goran Hallmans, Per Lenner, Toby J. Athersuch, Manolis Kogevinas, Euripides G. Stephanou, Antonis Myridakis, Lucia Fazzo, Marco De Santis, Pietro Comba, Hannu Kiviranta, Panu Rantakokko, Riikka Airaksinen, Paivi Ruokojarvi, Mark Gilthorpe, Sarah Fleming, Thomas Fleming, Yu Kang Tu, Bo Jonsson, Thomas Lundh, Wei J. Chen, Wen Chung Lee, Chuhsing Kate Hsiao, Kuo Liong Chien, Po Hsiu Kuo

Research output: Contribution to journalArticle

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Abstract

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.

Original languageEnglish
Article number42870
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - Feb 22 2017

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Smoke
Thrombin Receptors
Tobacco
Cardiovascular Diseases
Leukocytes
Smoking
Heme Oxygenase (Decyclizing)
Environmental Exposure
Prothrombin
DNA Methylation
Epigenomics
Thrombin
Glycoproteins
Oxidative Stress
Blood Platelets
Genome
Apoptosis
Gene Expression
Health
Population

ASJC Scopus subject areas

  • General

Cite this

Chatziioannou, A., Georgiadis, P., Hebels, D. G., Liampa, I., Valavanis, I., Bergdahl, I. A., ... Kuo, P. H. (2017). Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases. Scientific Reports, 7, [42870]. https://doi.org/10.1038/srep42870

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases. / Chatziioannou, Aristotelis; Georgiadis, Panagiotis; Hebels, Dennie G.; Liampa, Irene; Valavanis, Ioannis; Bergdahl, Ingvar A.; Johansson, Anders; Palli, Domenico; Chadeau-Hyam, Marc; Siskos, Alexandros P.; Keun, Hector; Botsivali, Maria; De Kok, Theo M.C.M.; Pérez, Almudena Espín; Kleinjans, Jos C.S.; Vineis, Paolo; Kyrtopoulos, Soterios A.; Gottschalk, Ralph; Van Leeuwen, Danitsja; Timmermans, Leen; Bendinelli, Benedetta; Kelly, Rachel; Vermeulen, Roel; Portengen, Lutzen; Saberi-Hosnijeh, Fatemeh; Melin, Beatrice; Hallmans, Goran; Lenner, Per; Athersuch, Toby J.; Kogevinas, Manolis; Stephanou, Euripides G.; Myridakis, Antonis; Fazzo, Lucia; De Santis, Marco; Comba, Pietro; Kiviranta, Hannu; Rantakokko, Panu; Airaksinen, Riikka; Ruokojarvi, Paivi; Gilthorpe, Mark; Fleming, Sarah; Fleming, Thomas; Tu, Yu Kang; Jonsson, Bo; Lundh, Thomas; Chen, Wei J.; Lee, Wen Chung; Hsiao, Chuhsing Kate; Chien, Kuo Liong; Kuo, Po Hsiu.

In: Scientific Reports, Vol. 7, 42870, 22.02.2017.

Research output: Contribution to journalArticle

Chatziioannou, A, Georgiadis, P, Hebels, DG, Liampa, I, Valavanis, I, Bergdahl, IA, Johansson, A, Palli, D, Chadeau-Hyam, M, Siskos, AP, Keun, H, Botsivali, M, De Kok, TMCM, Pérez, AE, Kleinjans, JCS, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, Van Leeuwen, D, Timmermans, L, Bendinelli, B, Kelly, R, Vermeulen, R, Portengen, L, Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Kiviranta, H, Rantakokko, P, Airaksinen, R, Ruokojarvi, P, Gilthorpe, M, Fleming, S, Fleming, T, Tu, YK, Jonsson, B, Lundh, T, Chen, WJ, Lee, WC, Hsiao, CK, Chien, KL & Kuo, PH 2017, 'Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases', Scientific Reports, vol. 7, 42870. https://doi.org/10.1038/srep42870
Chatziioannou A, Georgiadis P, Hebels DG, Liampa I, Valavanis I, Bergdahl IA et al. Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases. Scientific Reports. 2017 Feb 22;7. 42870. https://doi.org/10.1038/srep42870
Chatziioannou, Aristotelis ; Georgiadis, Panagiotis ; Hebels, Dennie G. ; Liampa, Irene ; Valavanis, Ioannis ; Bergdahl, Ingvar A. ; Johansson, Anders ; Palli, Domenico ; Chadeau-Hyam, Marc ; Siskos, Alexandros P. ; Keun, Hector ; Botsivali, Maria ; De Kok, Theo M.C.M. ; Pérez, Almudena Espín ; Kleinjans, Jos C.S. ; Vineis, Paolo ; Kyrtopoulos, Soterios A. ; Gottschalk, Ralph ; Van Leeuwen, Danitsja ; Timmermans, Leen ; Bendinelli, Benedetta ; Kelly, Rachel ; Vermeulen, Roel ; Portengen, Lutzen ; Saberi-Hosnijeh, Fatemeh ; Melin, Beatrice ; Hallmans, Goran ; Lenner, Per ; Athersuch, Toby J. ; Kogevinas, Manolis ; Stephanou, Euripides G. ; Myridakis, Antonis ; Fazzo, Lucia ; De Santis, Marco ; Comba, Pietro ; Kiviranta, Hannu ; Rantakokko, Panu ; Airaksinen, Riikka ; Ruokojarvi, Paivi ; Gilthorpe, Mark ; Fleming, Sarah ; Fleming, Thomas ; Tu, Yu Kang ; Jonsson, Bo ; Lundh, Thomas ; Chen, Wei J. ; Lee, Wen Chung ; Hsiao, Chuhsing Kate ; Chien, Kuo Liong ; Kuo, Po Hsiu. / Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases. In: Scientific Reports. 2017 ; Vol. 7.
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abstract = "We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.",
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AU - Liampa, Irene

AU - Valavanis, Ioannis

AU - Bergdahl, Ingvar A.

AU - Johansson, Anders

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AU - Siskos, Alexandros P.

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AU - Kogevinas, Manolis

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AU - Fazzo, Lucia

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AU - Tu, Yu Kang

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