Blood cell proteomics in chronic kidney disease

M. Bonomini, L. Pieroni, M. Ronci, V. Sirolli, Andrea Urbani

Research output: Contribution to journalArticle

Abstract

Background: The uremic syndrome mimes a systemic poisoning with the retention of numerous compounds which are normally removed by the kidney. The study of proteins and peptides, or proteomics, represents an important field of research for the investigation of blood and blood diseases. Methods and Materials: We focused our review on the results of proteomic investigations on blood cells of uremic patients with particular regard to the study of red blood cells, platelets, and monocytes. Results: In literature there are few, preliminary studies on platelets and monocytes while the knowledge on uremic erythrocytes is much wider. Proteomic investigations showed that erythrocyte membrane proteome of uremic patients, differs significantly from the proteome of healthy subjects, being characterized by an extensive remodeling which may influence visco-elastic properties of RBC such as deformability and involve diverse molecular pathways driving red blood cell signaling and removal. Conclusion: Proteomic technologies emerged as a useful tool in defining and characterizing both physiological and disease processes being able, among others, to give important insights into uremic anemia. © 2018 Bonomini et al.
Original languageEnglish
Pages (from-to)28-38
Number of pages11
JournalOpen Urology and Nephrology Journal
Volume11
Issue number1
DOIs
Publication statusPublished - 2018

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Chronic Renal Insufficiency
Proteomics
Blood Cells
Erythrocytes
Proteome
Monocytes
Blood Platelets
Physiological Phenomena
Hematologic Diseases
Erythrocyte Membrane
Poisoning
Anemia
Healthy Volunteers
Technology
Kidney
Peptides
Research
Proteins

Keywords

  • actin
  • calpain 1
  • clusterin
  • erythrocyte band 3 protein
  • glutathione
  • hemoglobin
  • peroxiredoxin 2
  • reactive oxygen metabolite
  • spectrin
  • superoxide dismutase
  • ubiquitinated protein, anemia
  • blood cell
  • cell adhesion
  • chronic kidney failure
  • cytokine production
  • erythrocyte
  • erythrocyte deformability
  • hemodialysis
  • hemolysis
  • human
  • mass spectrometry
  • monocyte
  • oxidative stress
  • pathophysiology
  • phagocytosis
  • priority journal
  • protein analysis
  • protein expression
  • proteomics
  • quality of life
  • Review
  • risk factor
  • signal transduction
  • systematic review
  • thrombocyte
  • uremia

Cite this

Blood cell proteomics in chronic kidney disease. / Bonomini, M.; Pieroni, L.; Ronci, M.; Sirolli, V.; Urbani, Andrea.

In: Open Urology and Nephrology Journal, Vol. 11, No. 1, 2018, p. 28-38.

Research output: Contribution to journalArticle

Bonomini, M. ; Pieroni, L. ; Ronci, M. ; Sirolli, V. ; Urbani, Andrea. / Blood cell proteomics in chronic kidney disease. In: Open Urology and Nephrology Journal. 2018 ; Vol. 11, No. 1. pp. 28-38.
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