Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients

Giulia Siravegna, Alberto Bardelli

Research output: Contribution to journalArticlepeer-review

Abstract

Most solid tumors, including colorectal cancers, shed cell-free DNA (ctDNA) in the blood. ctDNA can be analyzed to generate molecular profiles which capture the heterogeneity of the disease more comprehensively then tumor tissue biopsies. This approach commonly called 'liquid biopsy' can be applied to monitor response to therapy, to assess minimal residual disease and to uncover the emergence of drug resistance. This review will discuss current and future developments of ctDNA analysis in the clinical management of colorectal cancer patients.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalMolecular Oncology
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Circulating tumor DNA
  • Colorectal cancer
  • Liquid biopsy
  • Targeted therapy

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Medicine

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