Blood clotting in space

Luigi De Marco, R. Perris, M. R. Cozzi, M. Mazzucato

Research output: Contribution to journalArticle

Abstract

We describe herein a novel in vitro approach that can be used effectively to obtain valuable insights into the role of platelets, various coagulation proteins as well as proteins of the subendothelial extracellular matrix involved in the hemostatic and thrombotic processes occurring under microgravity. At difference with other experimental approaches proposed in the past our device operates in a closed system and under different shear forces, which better mimics flow conditions occurring in vessels. Furthermore our device by allowing real time monitoring of the thrombotic process and its underlying mechanisms can be regarded as a reliable system for the precise assessment of platelet function.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume18
Issue number2
Publication statusPublished - Apr 2004

Keywords

  • Blood flow
  • Microgravity
  • Platelets

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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  • Cite this

    De Marco, L., Perris, R., Cozzi, M. R., & Mazzucato, M. (2004). Blood clotting in space. Journal of Biological Regulators and Homeostatic Agents, 18(2), 187-192.