Blood coagulation changes in JW sarcoma, a new metastasizing tumour in mice

J. Chmielewska, A. Poggi, L. Mussoni, M. B. Donati, S. Garattini

Research output: Contribution to journalArticlepeer-review


A new murine tumour, which arose spontaneously in the lung, was characterized as a possible model of blood clotting changes during tumour and metastasis growth. The JW sarcoma (JWS), when transplanted s.c. in BALB/c mice, grows locally and spontaneously metastasizes to the lungs. The transplanted animals survive for 6 weeks. Thrombocytopenia and increased leukocyte count were observed during the metastasis growth. Concomitantly, increased fibrinogen level and reduced fibrinolytic activity were observed. At 4 weeks after tumour implantation, survival of labelled fibrinogen was prolonged. This experimental model may offer useful information on the haematological and blood clotting changes in cancer patients.

Original languageEnglish
Pages (from-to)1399-1407
Number of pages9
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number11
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Oncology


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