TY - JOUR
T1 - Blood coagulation changes in JW sarcoma, a new metastasizing tumour in mice
AU - Chmielewska, J.
AU - Poggi, A.
AU - Mussoni, L.
AU - Donati, M. B.
AU - Garattini, S.
PY - 1980
Y1 - 1980
N2 - A new murine tumour, which arose spontaneously in the lung, was characterized as a possible model of blood clotting changes during tumour and metastasis growth. The JW sarcoma (JWS), when transplanted s.c. in BALB/c mice, grows locally and spontaneously metastasizes to the lungs. The transplanted animals survive for 6 weeks. Thrombocytopenia and increased leukocyte count were observed during the metastasis growth. Concomitantly, increased fibrinogen level and reduced fibrinolytic activity were observed. At 4 weeks after tumour implantation, survival of labelled fibrinogen was prolonged. This experimental model may offer useful information on the haematological and blood clotting changes in cancer patients.
AB - A new murine tumour, which arose spontaneously in the lung, was characterized as a possible model of blood clotting changes during tumour and metastasis growth. The JW sarcoma (JWS), when transplanted s.c. in BALB/c mice, grows locally and spontaneously metastasizes to the lungs. The transplanted animals survive for 6 weeks. Thrombocytopenia and increased leukocyte count were observed during the metastasis growth. Concomitantly, increased fibrinogen level and reduced fibrinolytic activity were observed. At 4 weeks after tumour implantation, survival of labelled fibrinogen was prolonged. This experimental model may offer useful information on the haematological and blood clotting changes in cancer patients.
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U2 - 10.1016/0014-2964(80)90048-1
DO - 10.1016/0014-2964(80)90048-1
M3 - Article
C2 - 7227416
AN - SCOPUS:0019171791
VL - 16
SP - 1399
EP - 1407
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 11
ER -