Abstract
A new murine tumour, which arose spontaneously in the lung, was characterized as a possible model of blood clotting changes during tumour and metastasis growth. The JW sarcoma (JWS), when transplanted s.c. in BALB/c mice, grows locally and spontaneously metastasizes to the lungs. The transplanted animals survive for 6 weeks. Thrombocytopenia and increased leukocyte count were observed during the metastasis growth. Concomitantly, increased fibrinogen level and reduced fibrinolytic activity were observed. At 4 weeks after tumour implantation, survival of labelled fibrinogen was prolonged. This experimental model may offer useful information on the haematological and blood clotting changes in cancer patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1399-1407 |
| Number of pages | 9 |
| Journal | European Journal of Cancer and Clinical Oncology |
| Volume | 16 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1980 |
ASJC Scopus subject areas
- Oncology
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Chmielewska, J., Poggi, A., Mussoni, L., Donati, M. B., & Garattini, S. (1980). Blood coagulation changes in JW sarcoma, a new metastasizing tumour in mice. European Journal of Cancer and Clinical Oncology, 16(11), 1399-1407. https://doi.org/10.1016/0014-2964(80)90048-1