Blood eosinophil counts and arterial oxygen tension in acute asthma

D. Spallarossa, O. Sacco, D. Girosi, G. A. Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective - To investigate whether during acute asthma episodes a decrease in blood eosinophil count could correlate with the severity of the disease. Design - Prospective study on paediatric asthmatic patients admitted for acute asthma exacerbation between January 1992 and August 1993. All patients were regularly followed up in an outpatient clinic and had had a complete clinical evaluation 3, p0.05). Similarly, transcutaneous arterial oxygen pressure (PaO2) values measured during acute asthma exacerbations tended to be lower in infected patients, without, however, reaching statistical significance: 8.6 (0.7) v 10.1 (0.9) kPa, p>0.05). The correlation between the decrease in blood eosinophil count and PaO2, during the acute asthma exacerbations was significant in all the patients (r2 = 0.235, p=0.022) and in the non-infected patients (r2=0.653, p=0.015), but not in infected patients. In this latter subgroup, a significant negative correlation was found between blood neutrophil counts during acute asthma exacerbations and PaO2 (r2=349, p=0.026). Conclusions - During acute asthma exacerbations in atopic patients without clinical evidence of infection, the decrease in blood eosinophil count correlates significantly with the decrease in PaO2, further supporting the role of eosinophils in allergic asthma.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalArchives of Disease in Childhood
Volume73
Issue number4
Publication statusPublished - 1995

Keywords

  • Acute asthma
  • Arterial hypoxia
  • Blood eosinophils

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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