Blood glucose may condition factor VII levels in diabetic and normal subjects

A. Ceriello, D. Giugliano, A. Quatraro, P. Dello Russo, R. Torella

Research output: Contribution to journalArticle

Abstract

Increased factor VII levels have been reported in Type 1 (insulin-dependent) diabetic subjects. A direct correlation between fasting plasma glucose and factor VII level was found to exist in both diabetic and normal subjects. Induced-hyperglycaemia was able to increase factor VII levels in both diabetic patients and normal control subjects while, when euglycaemia was achieved in diabetic patients, factor VII values returned to normal range. This study shows that the level of factor VII may be directly conditioned by circulating blood glucose and, therefore, stresses the role of hyperglycaemia in conditioning coagulation abnormalities in diabetes mellitus.

Original languageEnglish
Pages (from-to)889-891
Number of pages3
JournalDiabetologia
Volume31
Issue number12
DOIs
Publication statusPublished - Dec 1988

Keywords

  • coagulation abnormalities
  • diabetes mellitus
  • euglycaemia
  • Factor VII
  • hyperglycaemia

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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