With respect to the controls an increased frequency of subjects with Le (a-b-) and a decreased frequency of Le (a-b+) and Kell-positive was found in the GU population studied, whilst in agreement with previous reports, no increased frequency of a particular blood group of the ABO system was detected. Le (a-b-) was not demonstrated to correlate with any of the parameters of gastric function considered. The absence of the Lewis antigens may probably imply an impairment in the mucosal resistance, especially in non-secretor ABH subjects, since Lewis antigens have been suggested to confer some protection on mucosal integrity for their mucoid character. The significance of the lower frequency of Kell-positive blood group is at present unknown. As far as DU is concerned, the major findings to be stressed are the significantly increased frequency of blood group B found in our series of patients, only reported previously by Berg (10), and the high frequency of P1+, first described in this report. No correlation was found between ABO blood groups and parameters of gastric function, in agreement with the few previously reported data, apart from the significantly lower MOA values found in group B DU than in non-B DU patients. The decreased MOA values found in blood group B DU and the increased frequency of Le (a-b-) in GU may lead to the suggestion that, in particular patients, an impaired mucosal resistance rather than a gastric hypersecretion is of importance in peptic ulcer development.
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)