Blood hypercoagulability secondary to experimental cerebral ischemia in the rabbit: Influence of a hyperdyslipemia induced by an atherogenic diet

P. L. Cipolli, P. Bo, E. Marchioni, C. Matti, F. Savoldi, A. Taccola

Research output: Contribution to journalArticlepeer-review

Abstract

Within the framework of a research carried out at the Neurological Institute of Pavia on experimental cerebral ischemia some biohumoral determinations were done on two groups of rabbits: one kept on a standard diet and the other on an atherogenic diet to induce dyslipemia. The aim was to find out whether induced ischemia produces an activation of the hemocoagulation processes and whether hyperdyslipemia constitutes an aggravating factor. In the animals on a standard diet there was a statistically significant increase in factor X A and a nonsignificant increase in parameter (r+k) on TEG (thromboelastogram) and of factor VIII C after embolization. In the hyperdyslipemic group the changes were definitely more marked and, in the case of factor VIII C and parameter (r+k), statistically significant, accompanied by slight variations in APTT and factor IX pointing in the same direction. We discuss the meaning of our findings.

Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalItalian Journal of Neurological Sciences
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 1991

Keywords

  • Experimental cerebral ischemia
  • hemocoagulation
  • hyperdyslipemia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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