Particulate matter (PM) exposure is associated with increased coagulation and thrombosis, but the biological mechanism has not yet been clarified. DNA methylation represents a potential mechanism because it can be modified by environmental factors. Foundry workers are exposed to PM components and showed increased cardiovascular risk. In a group of 63 steel workers we found that PM and zinc airborne levels were negatively associated with leukocyte DNA methylation in genes NOS3 and ET-1 (b=-1.1; p=0.002 and b=-1.5; p=0.003, for zinc exposure respectively in multivariate regression models; b=-0.9 with p=0.01 for PMI0 exposure and NOS3) and in turn, DNA hypo-methylation resulted associated with increased Endogenous Thrombin Potential (for NOS3 b=-45.0, p=0.00I; and for ET-1 b=-16.4, p=0.03). Our study based on healthy subject exposed in occupational setting, suggests that gene specific hypomethylation contributes to environmentally-induced hypercoagulability.
|Translated title of the contribution||Blood hypo-methylation mediates the effects of metal-rich airborne particles on blood coagulation: An occupational epidemiological study|
|Number of pages||3|
|Journal||Giornale Italiano di Medicina del Lavoro ed Ergonomia|
|Publication status||Published - Jul 2012|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health