Blood inflammatory proteins and risk of incident depression in the elderly

Paola Forti, Elisa Rietti, Nicoletta Pisacane, Valentina Olivelli, Erminia Mariani, Martina Chiappelli, Federico Licastro, Giovanni Ravaglia

Research output: Contribution to journalArticlepeer-review


Background: It is unclear whether high levels of blood inflammatory proteins are associated with the risk of developing depression in late life. Methods: Blood C-reactive protein, interleukin (IL)-6, α 1- antichymotrypsin (ACT), intercellular adhesion molecule 1, and tumor necrosis factor α were measured in an elderly cohort (n = 968). Major depression diagnosed according to clinical criteria and relevant depressive symptoms measured by the Geriatric Depression Scale (score ≥10) were assessed at baseline and 4 year later. Results: Baseline IL-6 and ACT were increased in both prevalent major depression and relevant depressive symptoms. Baseline ACT was increased in incident major depression. All associations weakened below significance after adjustment for possible confounders and multiple comparisons. Conclusions: Blood inflammatory proteins do not predict the risk of developing depression in older age.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalDementia and Geriatric Cognitive Disorders
Issue number1
Publication statusPublished - Feb 2010


  • Affective disorders in the elderly
  • Inflammatory markers
  • Risk of late-life depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience


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