Blood levels of ditazole and inhibition of platelet aggregation in man

G. de Gaetano, L. Dal Bo, S. Villa, E. Mussini, F. Marcucci

Research output: Contribution to journalArticle

Abstract

5 healthy volunteers (3 males, 2 females, aged 22-35 years) were given 600 mg ditazole (Ageroplas®) every 12 hr (9.00 a.m. and 9.00 p.m.) for 10 days. Venous blood was collected from all volunteers at 9.00 and 11.00 a.m. on days 0, 3, 5, 7 and 10. The threshold concentrations of adrenaline inducing two distinct waves of platelet aggregation (Born's method) within 3 min were determined each time. Blood levels of ditazole were measured by a gaschromatographic technique using a nitrogen-phorphorus selective detector. The average blood levels of the drug ranged between 0.84 and 1.30 μg/ml at 9.00 a.m., and between 1.93 and 2.85 μg/ml at 11.00 a.m. Inhibition of platelet aggregation (expressed by a grading system in arbitrary units) ranged between 1.6 and 2.0 at 9.00 a.m. and between 2.0 and 2.4 at 11.00 a.m. The fluctuations of blood levels and platelet aggregation inhibitory activity of ditazole observed during the study period were virtually the same. It is suggested that the treatment schedule used in the present study results in blood levels of ditazole sufficient to reveal any consistent alteration of platelet function in normal subjects.

Original languageEnglish
Pages (from-to)496-497
Number of pages2
JournalArzneimittel-Forschung/Drug Research
Volume30
Issue number3
Publication statusPublished - 1980

Fingerprint

ditazol
Platelets
Platelet Aggregation
Blood
Agglomeration
Blood Platelets
Epinephrine
Volunteers
Appointments and Schedules
Healthy Volunteers
Nitrogen
Detectors
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

de Gaetano, G., Dal Bo, L., Villa, S., Mussini, E., & Marcucci, F. (1980). Blood levels of ditazole and inhibition of platelet aggregation in man. Arzneimittel-Forschung/Drug Research, 30(3), 496-497.

Blood levels of ditazole and inhibition of platelet aggregation in man. / de Gaetano, G.; Dal Bo, L.; Villa, S.; Mussini, E.; Marcucci, F.

In: Arzneimittel-Forschung/Drug Research, Vol. 30, No. 3, 1980, p. 496-497.

Research output: Contribution to journalArticle

de Gaetano, G, Dal Bo, L, Villa, S, Mussini, E & Marcucci, F 1980, 'Blood levels of ditazole and inhibition of platelet aggregation in man', Arzneimittel-Forschung/Drug Research, vol. 30, no. 3, pp. 496-497.
de Gaetano, G. ; Dal Bo, L. ; Villa, S. ; Mussini, E. ; Marcucci, F. / Blood levels of ditazole and inhibition of platelet aggregation in man. In: Arzneimittel-Forschung/Drug Research. 1980 ; Vol. 30, No. 3. pp. 496-497.
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