Blood levels of homocysteine, folate, vitamin B6 and B 12 in women using oral contraceptives compared to non-users

Federico Lussana, Maddalena L. Zighetti, Paolo Bucciarelli, Massimo Cugno, Marco Cattaneo

Research output: Contribution to journalArticle


Background and objectives: To compare the levels of total homocysteine (tHcy), folate, vitamin B6 and B12, in women not using oral contraceptives (OC) vs. those using OC. Materials and methods: 219 healthy women were enrolled in the study; 159 of them had not been using OC for at least 12 months prior to their enrolment, while 60 were on regular OC treatment. Results: The median levels of vitamin B6 and B12 were significantly lower in OC users than in non-users (24.2 vs. 32.9 nmol/l, p=0.029; 278 vs. 429 ng/ml, p6 and B12 levels. Since low vitamin B6 levels are independently associated with heightened risks for arterial and venous thromboembolism (TE), they could partly account for the increased TE risk of OC users.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalThrombosis Research
Issue number1-2
Publication statusPublished - 2004


  • Folate
  • Homocysteine
  • Oral contraceptives
  • Thromboembolism
  • Vitamin B
  • Vitamin B

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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