Blood levels of vitamin E, polyunsaturated fatty acids of phospholipids, lipoperoxides and glutathione peroxidase in patients affected with seborrheic dermatitis

S. Passi, A. Morrone, C. De Luca, M. Picardo, F. Ippolito

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma levels of vitamin E (Vit E) and polyunsaturated fatty acids of phospholipids (PUFA-PL) as well as erythrocyte glutathione peroxidase (GSH-Px) activity are significantly lower (P <0.001) in patients with seborrheic dermatitis (SD), both HIV sero-positive or HIV sero-negative, than in control subjects. No differences are found between HIV sero-positive and sero-negative individuals with SD. The deficiency of PUFA-PL (mainly C20: 3 n-6, C20: 4 n-6 and C22: 6 n-3) which is accompanied by a significant increase of saturated palmitic and stearic acids (P <0.001), does not appear to be associated with an active lipoperoxidative process in the plasma. The significant blood deficiency of Vit E, GSH-Px, and particularly of PUFA-PL, may play a pathogenetic role in seborrheic dermatitis.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalJournal of Dermatological Science
Volume2
Issue number3
DOIs
Publication statusPublished - 1991

Keywords

  • AIDS
  • Glutathione peroxidase
  • Lipoperoxides
  • Phospholipids
  • Polyunsaturated fatty acids
  • Seborrheic dermatitis
  • Vitamin E

ASJC Scopus subject areas

  • Dermatology

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