TY - JOUR
T1 - Blood lipids profile in hyperlipidemic children undergoing different dietary long chain polyunsaturated supplementations
T2 - A preliminary clinical trial
AU - Verduci, Elvira
AU - Agostoni, Carlo
AU - Radaelli, Giovanni
AU - Banderali, Giuseppe
AU - Riva, Enrica
AU - Giovannini, Marcello
PY - 2014
Y1 - 2014
N2 - The aim of this preliminary study was to explore the effect size of different dietary long chain polyunsaturated supplementations on blood lipid profile in children with primary hyperlipidemia. Thirty-six children (8-13 years) were recruited. After an 8-week stabilization period on the Step I diet, they were randomized to additionally receive for a 16-week period one capsule (500mg) daily of docosahexaenoic acid (DHA) alone or a DHA plus eicosapentaenoic acid (EPA) mixture (45.6% DHA; 41.6% EPA) or wheat germ oil (control). An effect size (as percentage change from baseline) of +8%,-12% and-16% for high-density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C ratio and triglycerides was observed in children supplemented with DHA, compared to +2%,-8% and-12%, respectively, in children supplemented with DHA plus EPA. This preliminary study suggests powered trials appear feasible and are warranted to evaluate efficacy of n-3 long-chain polyunsaturated fatty acid dietary supplementations on the blood lipid profile of children with primary hyperlipidemia.
AB - The aim of this preliminary study was to explore the effect size of different dietary long chain polyunsaturated supplementations on blood lipid profile in children with primary hyperlipidemia. Thirty-six children (8-13 years) were recruited. After an 8-week stabilization period on the Step I diet, they were randomized to additionally receive for a 16-week period one capsule (500mg) daily of docosahexaenoic acid (DHA) alone or a DHA plus eicosapentaenoic acid (EPA) mixture (45.6% DHA; 41.6% EPA) or wheat germ oil (control). An effect size (as percentage change from baseline) of +8%,-12% and-16% for high-density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C ratio and triglycerides was observed in children supplemented with DHA, compared to +2%,-8% and-12%, respectively, in children supplemented with DHA plus EPA. This preliminary study suggests powered trials appear feasible and are warranted to evaluate efficacy of n-3 long-chain polyunsaturated fatty acid dietary supplementations on the blood lipid profile of children with primary hyperlipidemia.
KW - DHA
KW - EPA
KW - Hyperlipidemia
KW - LCPUFA
UR - http://www.scopus.com/inward/record.url?scp=84898439139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898439139&partnerID=8YFLogxK
U2 - 10.3109/09637486.2013.858239
DO - 10.3109/09637486.2013.858239
M3 - Article
C2 - 24228803
AN - SCOPUS:84898439139
VL - 65
SP - 375
EP - 379
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
SN - 0963-7486
IS - 3
ER -