Blood O2 affinity and maximal O2 consumption in elite bicycle racers

A. Veicsteinas, M. Samaja, M. Gussoni, P. Cerretelli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The PO2 at which hemoglobin is half-saturated with O2 (P50) at 37°C, PCO2 = 42 Torr, measured pH and 2,3-diphosphoglycerate-to-hemoglobin concentration ratio ([2,3-DPG]/[Hb]) values, Hill's coefficient (n) at rest, and maximal O2 consumption (V̇O2(max)) were determined in 11 world-class professional bicycle racers off-season (control, C), after 3 mo of 3 h daily training (preseason, PrS), and after additional 6 mo of competitions (competitive season, CoS). The results indicate that the P50 observed in trained athletes was the same as that of a comparable group of sedentary subjects (Sed) under the same conditions of pH, PCO2, and [2,3-DPG]/[Hb] and was similar to that obtained after 'normalization' in respect to pH and the [2,3-DPG]/[Hb]; [2,3-DPG]/[Hb] increased as a function of training from 0.72 to 0.95 (P <0.001); the slope of the central portion of the O2 equilibrium curve (OEC) was nearly unaffected by endurance training as indicated by the n value (n(CoS) = 2.70 ± 0.08; n(Sed) = 2.65 ± 0.08); and V̇O2(max) increased in the course of training 7 and 9% (P <0.001), respectively, when expressed in absolute units or per kilogram body weight. The V̇O2(max) predicted on the basis of a computer simulation does not increase significantly as a consequence of the measured rise in [2,3-DPG]. Therefore, the observed increase of V̇O2(max) cannot be explained with adaptive changes of the OEC. The present results differ from previous findings reported in other types of athletes.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume57
Issue number1
Publication statusPublished - 1984

Fingerprint

2,3-Diphosphoglycerate
Athletes
Hemoglobins
Computer Simulation
Body Weight

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Blood O2 affinity and maximal O2 consumption in elite bicycle racers. / Veicsteinas, A.; Samaja, M.; Gussoni, M.; Cerretelli, P.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 57, No. 1, 1984, p. 52-58.

Research output: Contribution to journalArticle

Veicsteinas, A. ; Samaja, M. ; Gussoni, M. ; Cerretelli, P. / Blood O2 affinity and maximal O2 consumption in elite bicycle racers. In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 1984 ; Vol. 57, No. 1. pp. 52-58.
@article{cfc58d817bd24e74a630cf88d7e50fa6,
title = "Blood O2 affinity and maximal O2 consumption in elite bicycle racers",
abstract = "The PO2 at which hemoglobin is half-saturated with O2 (P50) at 37°C, PCO2 = 42 Torr, measured pH and 2,3-diphosphoglycerate-to-hemoglobin concentration ratio ([2,3-DPG]/[Hb]) values, Hill's coefficient (n) at rest, and maximal O2 consumption (V̇O2(max)) were determined in 11 world-class professional bicycle racers off-season (control, C), after 3 mo of 3 h daily training (preseason, PrS), and after additional 6 mo of competitions (competitive season, CoS). The results indicate that the P50 observed in trained athletes was the same as that of a comparable group of sedentary subjects (Sed) under the same conditions of pH, PCO2, and [2,3-DPG]/[Hb] and was similar to that obtained after 'normalization' in respect to pH and the [2,3-DPG]/[Hb]; [2,3-DPG]/[Hb] increased as a function of training from 0.72 to 0.95 (P <0.001); the slope of the central portion of the O2 equilibrium curve (OEC) was nearly unaffected by endurance training as indicated by the n value (n(CoS) = 2.70 ± 0.08; n(Sed) = 2.65 ± 0.08); and V̇O2(max) increased in the course of training 7 and 9{\%} (P <0.001), respectively, when expressed in absolute units or per kilogram body weight. The V̇O2(max) predicted on the basis of a computer simulation does not increase significantly as a consequence of the measured rise in [2,3-DPG]. Therefore, the observed increase of V̇O2(max) cannot be explained with adaptive changes of the OEC. The present results differ from previous findings reported in other types of athletes.",
author = "A. Veicsteinas and M. Samaja and M. Gussoni and P. Cerretelli",
year = "1984",
language = "English",
volume = "57",
pages = "52--58",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Blood O2 affinity and maximal O2 consumption in elite bicycle racers

AU - Veicsteinas, A.

AU - Samaja, M.

AU - Gussoni, M.

AU - Cerretelli, P.

PY - 1984

Y1 - 1984

N2 - The PO2 at which hemoglobin is half-saturated with O2 (P50) at 37°C, PCO2 = 42 Torr, measured pH and 2,3-diphosphoglycerate-to-hemoglobin concentration ratio ([2,3-DPG]/[Hb]) values, Hill's coefficient (n) at rest, and maximal O2 consumption (V̇O2(max)) were determined in 11 world-class professional bicycle racers off-season (control, C), after 3 mo of 3 h daily training (preseason, PrS), and after additional 6 mo of competitions (competitive season, CoS). The results indicate that the P50 observed in trained athletes was the same as that of a comparable group of sedentary subjects (Sed) under the same conditions of pH, PCO2, and [2,3-DPG]/[Hb] and was similar to that obtained after 'normalization' in respect to pH and the [2,3-DPG]/[Hb]; [2,3-DPG]/[Hb] increased as a function of training from 0.72 to 0.95 (P <0.001); the slope of the central portion of the O2 equilibrium curve (OEC) was nearly unaffected by endurance training as indicated by the n value (n(CoS) = 2.70 ± 0.08; n(Sed) = 2.65 ± 0.08); and V̇O2(max) increased in the course of training 7 and 9% (P <0.001), respectively, when expressed in absolute units or per kilogram body weight. The V̇O2(max) predicted on the basis of a computer simulation does not increase significantly as a consequence of the measured rise in [2,3-DPG]. Therefore, the observed increase of V̇O2(max) cannot be explained with adaptive changes of the OEC. The present results differ from previous findings reported in other types of athletes.

AB - The PO2 at which hemoglobin is half-saturated with O2 (P50) at 37°C, PCO2 = 42 Torr, measured pH and 2,3-diphosphoglycerate-to-hemoglobin concentration ratio ([2,3-DPG]/[Hb]) values, Hill's coefficient (n) at rest, and maximal O2 consumption (V̇O2(max)) were determined in 11 world-class professional bicycle racers off-season (control, C), after 3 mo of 3 h daily training (preseason, PrS), and after additional 6 mo of competitions (competitive season, CoS). The results indicate that the P50 observed in trained athletes was the same as that of a comparable group of sedentary subjects (Sed) under the same conditions of pH, PCO2, and [2,3-DPG]/[Hb] and was similar to that obtained after 'normalization' in respect to pH and the [2,3-DPG]/[Hb]; [2,3-DPG]/[Hb] increased as a function of training from 0.72 to 0.95 (P <0.001); the slope of the central portion of the O2 equilibrium curve (OEC) was nearly unaffected by endurance training as indicated by the n value (n(CoS) = 2.70 ± 0.08; n(Sed) = 2.65 ± 0.08); and V̇O2(max) increased in the course of training 7 and 9% (P <0.001), respectively, when expressed in absolute units or per kilogram body weight. The V̇O2(max) predicted on the basis of a computer simulation does not increase significantly as a consequence of the measured rise in [2,3-DPG]. Therefore, the observed increase of V̇O2(max) cannot be explained with adaptive changes of the OEC. The present results differ from previous findings reported in other types of athletes.

UR - http://www.scopus.com/inward/record.url?scp=0021176615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021176615&partnerID=8YFLogxK

M3 - Article

VL - 57

SP - 52

EP - 58

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -