Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial

Alberto Zanchetti; Lisheng Liu; Giuseppe Mancia; Gianfranco Parati; Guido Grassi; Marco Stramba-Badiale; Vincenzo Silani; Grzegorz Bilo; Giovanni Corrao; Antonella Zambon; Lorenza Scotti; Xinhua Zhang; Hayyan Wang; Yuqing Zhang; Xuezhong Zhang; Ting Rui Guan; Eivind Berge; Josep Redon; Krzysztof Narkiewicz; Anna Dominiczak; Peter Nilsson; Margus Viigimaa; Stéphane Laurent; Enrico Agabiti-Rosei; Zhaosu Wu; Dingliang Zhu; José Luis Rodicio; Luis Miguel Ruilope; Nieves Martell-Claros; Fernando Pinto; Roland E. Schmieder; Michel Burnier; Maciej Banach; Renata Cifkova; Csaba Farsang; Alexandra Konradi; Irina Lazareva; Yuriy Sirenko; Maria Dorobantu; Arman Postadzhiyan; Rok Accetto; Bojan Jelakovic; Dragan Lovic; Athanasios J. Manolis; Philippos Stylianou; Serap Erdine; Dror Dicker; Gangzhi Wei; Chengbin Xu; Hengge Xie; Antonio Coca; John O'Brien; Gary Ford

doi:10.1097/HJH.0000000000000254

Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial

Alberto Zanchetti, Lisheng Liu, Giuseppe Mancia, Gianfranco Parati, Guido Grassi, Marco Stramba-Badiale, Vincenzo Silani, Grzegorz Bilo, Giovanni Corrao, Antonella Zambon, Lorenza Scotti, Xinhua Zhang, Hayyan Wang, Yuqing Zhang, Xuezhong Zhang, Ting Rui Guan, Eivind Berge, Josep Redon, Krzysztof Narkiewicz, Anna DominiczakPeter Nilsson, Margus Viigimaa, Stéphane Laurent, Enrico Agabiti-Rosei, Zhaosu Wu, Dingliang Zhu, José Luis Rodicio, Luis Miguel Ruilope, Nieves Martell-Claros, Fernando Pinto, Roland E. Schmieder, Michel Burnier, Maciej Banach, Renata Cifkova, Csaba Farsang, Alexandra Konradi, Irina Lazareva, Yuriy Sirenko, Maria Dorobantu, Arman Postadzhiyan, Rok Accetto, Bojan Jelakovic, Dragan Lovic, Athanasios J. Manolis, Philippos Stylianou, Serap Erdine, Dror Dicker, Gangzhi Wei, Chengbin Xu, Hengge Xie, Antonio Coca, John O'Brien, Gary Ford

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND AND OBJECTIVES:: The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design. PROTOCOL DESIGN:: The European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment trial is a prospective multinational, randomized trial with a 3×2 factorial design comparing: three different SBP targets (1,

Original language	English
Pages (from-to)	1888-1897
Number of pages	10
Journal	Journal of Hypertension
Volume	32
Issue number	9
DOIs	https://doi.org/10.1097/HJH.0000000000000254
Publication status	Published - 2014

Keywords

blood pressure
cognitive decline
low-density lipoprotein cholesterol
randomized controlled trial
secondary prevention
stroke

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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10.1097/HJH.0000000000000254

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Zanchetti, A., Liu, L., Mancia, G., Parati, G., Grassi, G., Stramba-Badiale, M., Silani, V., Bilo, G., Corrao, G., Zambon, A., Scotti, L., Zhang, X., Wang, H., Zhang, Y., Zhang, X., Guan, T. R., Berge, E., Redon, J., Narkiewicz, K., ... Ford, G. (2014). Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. Journal of Hypertension, 32(9), 1888-1897. https://doi.org/10.1097/HJH.0000000000000254

Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient : Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. / Zanchetti, Alberto; Liu, Lisheng; Mancia, Giuseppe; Parati, Gianfranco ; Grassi, Guido ; Stramba-Badiale, Marco ; Silani, Vincenzo ; Bilo, Grzegorz; Corrao, Giovanni; Zambon, Antonella; Scotti, Lorenza; Zhang, Xinhua; Wang, Hayyan; Zhang, Yuqing; Zhang, Xuezhong; Guan, Ting Rui; Berge, Eivind; Redon, Josep; Narkiewicz, Krzysztof; Dominiczak, Anna; Nilsson, Peter; Viigimaa, Margus; Laurent, Stéphane; Agabiti-Rosei, Enrico; Wu, Zhaosu; Zhu, Dingliang; Rodicio, José Luis; Ruilope, Luis Miguel; Martell-Claros, Nieves; Pinto, Fernando; Schmieder, Roland E.; Burnier, Michel; Banach, Maciej; Cifkova, Renata; Farsang, Csaba; Konradi, Alexandra; Lazareva, Irina; Sirenko, Yuriy; Dorobantu, Maria; Postadzhiyan, Arman; Accetto, Rok; Jelakovic, Bojan; Lovic, Dragan; Manolis, Athanasios J.; Stylianou, Philippos; Erdine, Serap; Dicker, Dror; Wei, Gangzhi; Xu, Chengbin; Xie, Hengge; Coca, Antonio; O'Brien, John; Ford, Gary.

In: Journal of Hypertension, Vol. 32, No. 9, 2014, p. 1888-1897.

Research output: Contribution to journal › Article › peer-review

Zanchetti, A, Liu, L, Mancia, G, Parati, G , Grassi, G , Stramba-Badiale, M , Silani, V , Bilo, G, Corrao, G, Zambon, A, Scotti, L, Zhang, X, Wang, H, Zhang, Y, Zhang, X, Guan, TR, Berge, E, Redon, J, Narkiewicz, K, Dominiczak, A, Nilsson, P, Viigimaa, M, Laurent, S, Agabiti-Rosei, E, Wu, Z, Zhu, D, Rodicio, JL, Ruilope, LM, Martell-Claros, N, Pinto, F, Schmieder, RE, Burnier, M, Banach, M, Cifkova, R, Farsang, C, Konradi, A, Lazareva, I, Sirenko, Y, Dorobantu, M, Postadzhiyan, A, Accetto, R, Jelakovic, B, Lovic, D, Manolis, AJ, Stylianou, P, Erdine, S, Dicker, D, Wei, G, Xu, C, Xie, H, Coca, A, O'Brien, J & Ford, G 2014, 'Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial', Journal of Hypertension, vol. 32, no. 9, pp. 1888-1897. https://doi.org/10.1097/HJH.0000000000000254

Zanchetti A, Liu L, Mancia G, Parati G , Grassi G , Stramba-Badiale M et al. Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. Journal of Hypertension. 2014;32(9):1888-1897. https://doi.org/10.1097/HJH.0000000000000254

Zanchetti, Alberto ; Liu, Lisheng ; Mancia, Giuseppe ; Parati, Gianfranco ; Grassi, Guido ; Stramba-Badiale, Marco ; Silani, Vincenzo ; Bilo, Grzegorz ; Corrao, Giovanni ; Zambon, Antonella ; Scotti, Lorenza ; Zhang, Xinhua ; Wang, Hayyan ; Zhang, Yuqing ; Zhang, Xuezhong ; Guan, Ting Rui ; Berge, Eivind ; Redon, Josep ; Narkiewicz, Krzysztof ; Dominiczak, Anna ; Nilsson, Peter ; Viigimaa, Margus ; Laurent, Stéphane ; Agabiti-Rosei, Enrico ; Wu, Zhaosu ; Zhu, Dingliang ; Rodicio, José Luis ; Ruilope, Luis Miguel ; Martell-Claros, Nieves ; Pinto, Fernando ; Schmieder, Roland E. ; Burnier, Michel ; Banach, Maciej ; Cifkova, Renata ; Farsang, Csaba ; Konradi, Alexandra ; Lazareva, Irina ; Sirenko, Yuriy ; Dorobantu, Maria ; Postadzhiyan, Arman ; Accetto, Rok ; Jelakovic, Bojan ; Lovic, Dragan ; Manolis, Athanasios J. ; Stylianou, Philippos ; Erdine, Serap ; Dicker, Dror ; Wei, Gangzhi ; Xu, Chengbin ; Xie, Hengge ; Coca, Antonio ; O'Brien, John ; Ford, Gary. / Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient : Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. In: Journal of Hypertension. 2014 ; Vol. 32, No. 9. pp. 1888-1897.

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abstract = "BACKGROUND AND OBJECTIVES:: The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design. PROTOCOL DESIGN:: The European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment trial is a prospective multinational, randomized trial with a 3×2 factorial design comparing: three different SBP targets (1, ",

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AU - Parati, Gianfranco

AU - Grassi, Guido

AU - Stramba-Badiale, Marco

AU - Silani, Vincenzo

AU - Bilo, Grzegorz

AU - Corrao, Giovanni

AU - Zambon, Antonella

AU - Scotti, Lorenza

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AU - Rodicio, José Luis

AU - Ruilope, Luis Miguel

AU - Martell-Claros, Nieves

AU - Pinto, Fernando

AU - Schmieder, Roland E.

AU - Burnier, Michel

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AU - Cifkova, Renata

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