TY - JOUR
T1 - Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient
T2 - Design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial
AU - Zanchetti, Alberto
AU - Liu, Lisheng
AU - Mancia, Giuseppe
AU - Parati, Gianfranco
AU - Grassi, Guido
AU - Stramba-Badiale, Marco
AU - Silani, Vincenzo
AU - Bilo, Grzegorz
AU - Corrao, Giovanni
AU - Zambon, Antonella
AU - Scotti, Lorenza
AU - Zhang, Xinhua
AU - Wang, Hayyan
AU - Zhang, Yuqing
AU - Zhang, Xuezhong
AU - Guan, Ting Rui
AU - Berge, Eivind
AU - Redon, Josep
AU - Narkiewicz, Krzysztof
AU - Dominiczak, Anna
AU - Nilsson, Peter
AU - Viigimaa, Margus
AU - Laurent, Stéphane
AU - Agabiti-Rosei, Enrico
AU - Wu, Zhaosu
AU - Zhu, Dingliang
AU - Rodicio, José Luis
AU - Ruilope, Luis Miguel
AU - Martell-Claros, Nieves
AU - Pinto, Fernando
AU - Schmieder, Roland E.
AU - Burnier, Michel
AU - Banach, Maciej
AU - Cifkova, Renata
AU - Farsang, Csaba
AU - Konradi, Alexandra
AU - Lazareva, Irina
AU - Sirenko, Yuriy
AU - Dorobantu, Maria
AU - Postadzhiyan, Arman
AU - Accetto, Rok
AU - Jelakovic, Bojan
AU - Lovic, Dragan
AU - Manolis, Athanasios J.
AU - Stylianou, Philippos
AU - Erdine, Serap
AU - Dicker, Dror
AU - Wei, Gangzhi
AU - Xu, Chengbin
AU - Xie, Hengge
AU - Coca, Antonio
AU - O'Brien, John
AU - Ford, Gary
PY - 2014
Y1 - 2014
N2 - BACKGROUND AND OBJECTIVES:: The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design. PROTOCOL DESIGN:: The European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment trial is a prospective multinational, randomized trial with a 3×2 factorial design comparing: three different SBP targets (1,
AB - BACKGROUND AND OBJECTIVES:: The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design. PROTOCOL DESIGN:: The European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment trial is a prospective multinational, randomized trial with a 3×2 factorial design comparing: three different SBP targets (1,
KW - blood pressure
KW - cognitive decline
KW - low-density lipoprotein cholesterol
KW - randomized controlled trial
KW - secondary prevention
KW - stroke
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U2 - 10.1097/HJH.0000000000000254
DO - 10.1097/HJH.0000000000000254
M3 - Article
C2 - 24979303
AN - SCOPUS:84906089553
VL - 32
SP - 1888
EP - 1897
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 9
ER -