Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

Steffen Weikert, Heiner Boeing, Tobias Pischon, Cornelia Weikert, Anja Olsen, Anne Tjonneland, Kim Overvad, Nikolaus Becker, Jakob Linseisen, Antonia Trichopoulou, Theodore Mountokalakis, Dimitrios Trichopoulos, Sabina Sieri, Domenico Palli, Paolo Vineis, Salvatore Panico, Petra H M Peeters, H. Bas Bueno-De-Mesquita, W. M Monique Verschuren, Borje LjungbergGoran Hallmans, Goran Berglund, Carlos A. González, Miren Dorronsoro, Aurelio Barricarte, M. J. Tormo, Naomi Allen, Andrew Roddam, Sheila Bingham, Kay Tee Khaw, Sabina Rinaldi, Pietro Ferrari, Teresa Norat, Elio Riboli

Research output: Contribution to journalArticlepeer-review

Abstract

Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood pressure was measured in 296,638 women and men, recruited in eight European countries during 1992-1998, 254,935 of whom provided information on antihypertensive medication. During a mean follow-up of 6.2 years, 250 cases of RCC were identified. Blood pressure was independently associated with risk of RCC. The relative risks for the highest versus the lowest category of systolic (≥160 mmHg vs.

Original languageEnglish
Pages (from-to)438-446
Number of pages9
JournalAmerican Journal of Epidemiology
Volume167
Issue number4
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Antihypertensive agents
  • Hypertension
  • Kidney neoplasms
  • Risk factors

ASJC Scopus subject areas

  • Epidemiology

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