Blood pressure control and inflammatory markers in type 2 diabetic patients treated with pioglitazone or rosiglitazone and metformin

Giuseppe Derosa, Elena Fogari, Arrigo F G Cicero, Angela D'Angelo, Leonardina Ciccarelli, Mario N. Piccinni, Fabio Pricolo, Sibilla A T Salvadeo, Alessia Gravina, Ilaria Ferrari, Roberto Fogari

Research output: Contribution to journalArticle

Abstract

The aim of the study was to assess the effects of the combination of metformin plus ploglitazone or rosiglitazone on glucose and blood pressure in type 2 diabetic patients with metabolic syndrome, as well as its tolerability in those patients. In this 12-month, multicentric, double-blind, randomized, controlled, parallel-group trial, all patients began with metformin. Patients were randomized for self-administration of either pioglitazone or rosiglitazone for 12 months. We assessed body mass index (BMI), glycemic: control (glycosylated hemoglobin [HbA1c], fasting and postprandial plasma glucose and insulin levels [FPG, PPG, FPI and PPI, respectively] and homeostasis model assessment [HOMA] index) and systolic and diastolic blood pressure (SBP and DBP, respectively), at baseline and at 3, 6, 9 and 12 months of treatment, as well as high-sensitivity C-reactive protein (hs-CRP), nitrites/nitrates and adiponectin (ADN) at baseline and at 12 months of treatment. Significant HbA1c. decreases were obtained after 9 (p

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalHypertension Research
Volume30
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • Diabetes mellitus
  • Metformin
  • Pioglitazone
  • Rosiglitazone
  • Thiazolidinediones

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Derosa, G., Fogari, E., Cicero, A. F. G., D'Angelo, A., Ciccarelli, L., Piccinni, M. N., Pricolo, F., Salvadeo, S. A. T., Gravina, A., Ferrari, I., & Fogari, R. (2007). Blood pressure control and inflammatory markers in type 2 diabetic patients treated with pioglitazone or rosiglitazone and metformin. Hypertension Research, 30(5), 387-394. https://doi.org/10.1291/hypres.30.387