Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): Multicentre, randomised controlled trial

Piero Ruggenenti, Annalisa Perna, Giacomina Loriga, Maria Ganeva, Bogdan Ene-Iordache, Marta Turturro, Maria Lesti, Elena Perticucci, Ivan Nediyalkov Chakarski, Daniela Leonardis, Giovanni Garini, Adalberto Sessa, Carlo Basile, Mirella Alpa, Renzo Scanziani, Gianbattista Sorba, Carmine Zoccali, Giuseppe Remuzzi

Research output: Contribution to journalArticle

Abstract

Background: In chronic nephropathies, inhibition of angiotensin-converting enzyme (ACE) is renoprotective, but can further renoprotection be achieved by reduction of blood pressure to lower than usual targets? We aimed to assess the effect of intensified versus conventional blood-pressure control on progression to end-stage renal disease. Methods: We undertook a multicentre, randomised controlled trial of patients with non-diabetic proteinuric nephropathies receiving background treatment with the ACE inhibitor ramipril (2·5-5 mg/day). We randomly assigned participants either conventional (diastolic

Original languageEnglish
Pages (from-to)939-946
Number of pages8
JournalLancet
Volume365
Issue number9463
DOIs
Publication statusPublished - Mar 12 2005

ASJC Scopus subject areas

  • Medicine(all)

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    Ruggenenti, P., Perna, A., Loriga, G., Ganeva, M., Ene-Iordache, B., Turturro, M., Lesti, M., Perticucci, E., Chakarski, I. N., Leonardis, D., Garini, G., Sessa, A., Basile, C., Alpa, M., Scanziani, R., Sorba, G., Zoccali, C., & Remuzzi, G. (2005). Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): Multicentre, randomised controlled trial. Lancet, 365(9463), 939-946. https://doi.org/10.1016/S0140-6736(05)71082-5