Blood-pressure control in the hypertensive population

Giuseppe Mancia, Roberto Sega, Camilla Milesi, Giancarlo Cesana, Alberto Zanchetti

Research output: Contribution to journalArticle

286 Citations (Scopus)

Abstract

Background: In large-scale surveys of individuals with hypertension those whose clinic blood pressure is reduced to 140/90 mmHg or less have been found to represent only a small fraction of the hypertensive population. We assessed whether these results arise because of a white-coat effect elevating clinic blood pressure. Methods: We randomly selected 2400 individuals from the town of Monza, Italy, and invited them to take part in our study. We measured clinic blood pressure as well as home (morning and evening measurements), and 24 h ambulatory blood pressure - ie, blood pressures largely devoid of a white-coat effect. Based on clinic blood pressure participants were then classified as normotensive, untreated hypertensive (clinic blood pressure > 140 mmHg systolic and/or > 90 mmHg diastolic), or treated hypertensive (having antihypertensive treatment). The mean blood pressures for each group were calculated. Findings: 1651 people took part in the study. The clinic blood pressure of treated hypertensives (n = 207; 146.9 [SD 18] mmHg/90.2 [8.6] mmHg) was only slightly less than in untreated hypertensives (n = 402; 148 [15.2] mmHg/93.3 [8] mmHg) and in both groups the blood pressure values were much greater than those of normotensive individuals (n = 1042; 119.5 [10.3] mmHg/78.1 [6.6] mmHg) p <0.001. Averaged home and 24 h blood pressures were lower than clinic blood pressures but similarly higher in untreated and treated hypertensive individuals when compared with normotensive individuals. This was also the case for day, and night average blood pressures. The number of treated hypertensive patients found to have blood pressures within the normal limits was small not only when based on clinic blood pressure values but also when based on ambulatory blood-pressure values. Interpretation: In the hypertensive population the number of patients with inadequate blood-pressure control is high not only when assessed in the clinic but also when assessed by ambulatory-blood-pressure monitoring or at home. The high blood-pressure values commonly found in treated hypertensive individuals cannot be accounted for by a white-coat effect but by a true lack of daily-life blood-pressure control.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalLancet
Volume349
Issue number9050
DOIs
Publication statusPublished - Feb 15 1997

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Blood Pressure
Population
Hypertension
Ambulatory Blood Pressure Monitoring
Antihypertensive Agents
Italy

ASJC Scopus subject areas

  • Medicine(all)

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Mancia, G., Sega, R., Milesi, C., Cesana, G., & Zanchetti, A. (1997). Blood-pressure control in the hypertensive population. Lancet, 349(9050), 454-457. https://doi.org/10.1016/S0140-6736(96)07099-7

Blood-pressure control in the hypertensive population. / Mancia, Giuseppe; Sega, Roberto; Milesi, Camilla; Cesana, Giancarlo; Zanchetti, Alberto.

In: Lancet, Vol. 349, No. 9050, 15.02.1997, p. 454-457.

Research output: Contribution to journalArticle

Mancia, G, Sega, R, Milesi, C, Cesana, G & Zanchetti, A 1997, 'Blood-pressure control in the hypertensive population', Lancet, vol. 349, no. 9050, pp. 454-457. https://doi.org/10.1016/S0140-6736(96)07099-7
Mancia G, Sega R, Milesi C, Cesana G, Zanchetti A. Blood-pressure control in the hypertensive population. Lancet. 1997 Feb 15;349(9050):454-457. https://doi.org/10.1016/S0140-6736(96)07099-7
Mancia, Giuseppe ; Sega, Roberto ; Milesi, Camilla ; Cesana, Giancarlo ; Zanchetti, Alberto. / Blood-pressure control in the hypertensive population. In: Lancet. 1997 ; Vol. 349, No. 9050. pp. 454-457.
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