Blood pressure in relation to three candidate genes in a Chinese population

Ji Guang Wang, Lifang Liu, Laura Zagato, Jinxiang Xie, Robert Fagard, Kugen Jin, Jinxiang Wang, Yan Li, Giuseppe Bianchi, Jan A. Staessen, Lisheng Liu

Research output: Contribution to journalArticle

Abstract

Objective: In a prospective analysis of a Caucasian population, we recently found that the genes encoding angiotensin-converting enzyme (ACE, I/D polymorphism), α-adducin (Gly460Trp) and aldosterone synthase (-344C/ T) jointly influence the incidence of hypertension. We therefore investigated the association between blood pressure and these three genes in a Chinese population. Methods: We genotyped 479 Han Chinese from 125 nuclear families recruited in northern China via random sampling (∼75%) and at specialized hypertension clinics (∼25%). We performed population-based and family-based association analyses using generalized estimating equations (GEE) and the quantitative transmission disequilibrium test (QTDT), respectively, while controlling for covariables. Results: The participants included 239 (49.9%) women and 132 (27.6%) hypertensive patients, of whom 77 took antihypertensive drugs. The blood pressure, measured at the subjects' homes, averaged 126/80 mmHg. Mean values of urinary sodium, potassium and Na+/K+ ratio were 226 mmol/day, 37 mmol/day and 6.31, respectively. In adjusted GEE analyses, systolic blood pressure was 9.3 mmHg (95% confidence interval 3.6-15.0 mmHg; P = 0.001) and 14.6 mmHg (95% confidence interval 3.4-25.8 mmHg; P = 0.01) higher in the ACE DD than II subjects among the α-adducin TrpTrp (n = 141) and aldosterone synthase CC (n = 33) homozygotes, respectively (P ≤ 0.05 for interactions of the ACE genotype with the α-adducin and aldosterone synthase polymorphisms). Among 40 informative offspring homozygous for the α-adducin Trp allele, systolic blood pressure was significantly associated with transmission of the ACE D allele (β = 5.5 mmHg; P = 0.046). Conclusions: The ACE I/D, α-adducin Gly460Trp and aldosterone synthase -344C/T polymorphisms interact to influence systolic blood pressure in Chinese, suggesting that these genes might indeed predispose to hypertension, especially in an ecogenetic context characterized by a high salt intake.

Original languageEnglish
Pages (from-to)937-944
Number of pages8
JournalJournal of Hypertension
Volume22
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • α-adducin gene
  • Aldosterone synthase
  • Angiotensin-converting enzyme
  • Blood pressure
  • Genetic mechanisms
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

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  • Cite this

    Wang, J. G., Liu, L., Zagato, L., Xie, J., Fagard, R., Jin, K., Wang, J., Li, Y., Bianchi, G., Staessen, J. A., & Liu, L. (2004). Blood pressure in relation to three candidate genes in a Chinese population. Journal of Hypertension, 22(5), 937-944. https://doi.org/10.1097/00004872-200405000-00015