TY - JOUR
T1 - Blood pressure in relation to three candidate genes in a Chinese population
AU - Wang, Ji Guang
AU - Liu, Lifang
AU - Zagato, Laura
AU - Xie, Jinxiang
AU - Fagard, Robert
AU - Jin, Kugen
AU - Wang, Jinxiang
AU - Li, Yan
AU - Bianchi, Giuseppe
AU - Staessen, Jan A.
AU - Liu, Lisheng
PY - 2004/5
Y1 - 2004/5
N2 - Objective: In a prospective analysis of a Caucasian population, we recently found that the genes encoding angiotensin-converting enzyme (ACE, I/D polymorphism), α-adducin (Gly460Trp) and aldosterone synthase (-344C/ T) jointly influence the incidence of hypertension. We therefore investigated the association between blood pressure and these three genes in a Chinese population. Methods: We genotyped 479 Han Chinese from 125 nuclear families recruited in northern China via random sampling (∼75%) and at specialized hypertension clinics (∼25%). We performed population-based and family-based association analyses using generalized estimating equations (GEE) and the quantitative transmission disequilibrium test (QTDT), respectively, while controlling for covariables. Results: The participants included 239 (49.9%) women and 132 (27.6%) hypertensive patients, of whom 77 took antihypertensive drugs. The blood pressure, measured at the subjects' homes, averaged 126/80 mmHg. Mean values of urinary sodium, potassium and Na+/K+ ratio were 226 mmol/day, 37 mmol/day and 6.31, respectively. In adjusted GEE analyses, systolic blood pressure was 9.3 mmHg (95% confidence interval 3.6-15.0 mmHg; P = 0.001) and 14.6 mmHg (95% confidence interval 3.4-25.8 mmHg; P = 0.01) higher in the ACE DD than II subjects among the α-adducin TrpTrp (n = 141) and aldosterone synthase CC (n = 33) homozygotes, respectively (P ≤ 0.05 for interactions of the ACE genotype with the α-adducin and aldosterone synthase polymorphisms). Among 40 informative offspring homozygous for the α-adducin Trp allele, systolic blood pressure was significantly associated with transmission of the ACE D allele (β = 5.5 mmHg; P = 0.046). Conclusions: The ACE I/D, α-adducin Gly460Trp and aldosterone synthase -344C/T polymorphisms interact to influence systolic blood pressure in Chinese, suggesting that these genes might indeed predispose to hypertension, especially in an ecogenetic context characterized by a high salt intake.
AB - Objective: In a prospective analysis of a Caucasian population, we recently found that the genes encoding angiotensin-converting enzyme (ACE, I/D polymorphism), α-adducin (Gly460Trp) and aldosterone synthase (-344C/ T) jointly influence the incidence of hypertension. We therefore investigated the association between blood pressure and these three genes in a Chinese population. Methods: We genotyped 479 Han Chinese from 125 nuclear families recruited in northern China via random sampling (∼75%) and at specialized hypertension clinics (∼25%). We performed population-based and family-based association analyses using generalized estimating equations (GEE) and the quantitative transmission disequilibrium test (QTDT), respectively, while controlling for covariables. Results: The participants included 239 (49.9%) women and 132 (27.6%) hypertensive patients, of whom 77 took antihypertensive drugs. The blood pressure, measured at the subjects' homes, averaged 126/80 mmHg. Mean values of urinary sodium, potassium and Na+/K+ ratio were 226 mmol/day, 37 mmol/day and 6.31, respectively. In adjusted GEE analyses, systolic blood pressure was 9.3 mmHg (95% confidence interval 3.6-15.0 mmHg; P = 0.001) and 14.6 mmHg (95% confidence interval 3.4-25.8 mmHg; P = 0.01) higher in the ACE DD than II subjects among the α-adducin TrpTrp (n = 141) and aldosterone synthase CC (n = 33) homozygotes, respectively (P ≤ 0.05 for interactions of the ACE genotype with the α-adducin and aldosterone synthase polymorphisms). Among 40 informative offspring homozygous for the α-adducin Trp allele, systolic blood pressure was significantly associated with transmission of the ACE D allele (β = 5.5 mmHg; P = 0.046). Conclusions: The ACE I/D, α-adducin Gly460Trp and aldosterone synthase -344C/T polymorphisms interact to influence systolic blood pressure in Chinese, suggesting that these genes might indeed predispose to hypertension, especially in an ecogenetic context characterized by a high salt intake.
KW - α-adducin gene
KW - Aldosterone synthase
KW - Angiotensin-converting enzyme
KW - Blood pressure
KW - Genetic mechanisms
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=2542440909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542440909&partnerID=8YFLogxK
U2 - 10.1097/00004872-200405000-00015
DO - 10.1097/00004872-200405000-00015
M3 - Article
C2 - 15097233
AN - SCOPUS:2542440909
VL - 22
SP - 937
EP - 944
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 5
ER -