Blood pressure lowering effects of rimonabant in obesity-related hypertension

Guido Grassi, F. Quarti-Trevano, G. Seravalle, F. Arenare, G. Brambilla, G. Mancia

Research output: Contribution to journalArticle

Abstract

Obesity-related hypertension represents a common clinical condition characterised by complex pathophysiological and therapeutic features. From a pathophysiological view point, results of experimental and animal studies have led to the hypothesis that neurogenic mechanisms participate in the development and progression of the disease. The hypothesis is based on the evidence that metabolic (i.e. insulin-resistance) and neural (sympathetic activation) alterations frequently co-exist in the obese hypertensive patient and that they reciprocally potentiate each other. From a therapeutic view point, the 2007 European Society of Hypertension/European Society of Cardiology emphasised the importance in this clinical condition of treatment not only through antihypertensive drugs but also via lifestyle changes and drug-induced interventions that reduce body weight. The four Rimonabant In Obesity (RIO) studies have shown that rimonabant can decrease body weight. A recent meta-analysis, based on the RIO results, showed that rimonabant, particularly in obese hypertensive patients, can also decrease - although modestly (2.8 mmHg for systolic and 2.2 mmHg for diastolic) - blood pressure. These effects, which appear to be triggered by the weight reduction induced by the drug, are clinically relevant because they contribute favourably to lower the elevated cardiovascular risk profile of the obese hypertensive patient.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalJournal of Neuroendocrinology
Volume20
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 2008

Keywords

  • Blood pressure
  • Obesity
  • Rimonabant
  • Sympathetic activity
  • Weight reduction

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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