Blood Pressure Reduction and Cardiovascular Outcomes: Past, Present, and Future

Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Hypertension has not always been recognized as a harbinger of cardiovascular complications and premature death. Only 70 years ago, hypertension was considered the body's adaptation to sclerotic blood vessel disease and essential to maintain organ perfusion; thus, treatment was regarded as undesirable. Epidemiologic studies have since established a strong linear relation between blood pressure and cardiovascular disease (CVD), and randomized trials have documented that blood pressure reductions by antihypertensive drugs confer cardiovascular protection, making the hypertension-related risk a reversible risk. There is now a consensus that blood pressure should be reduced to

Original languageEnglish
JournalThe American Journal of Cardiology
Issue number3 SUPPL.
Publication statusPublished - Aug 6 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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