Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension

Sebastian Ewen, Oliver Dörr, Christian Ukena, Dominik Linz, Bodo Cremers, Ulrich Laufs, Christian Hamm, Holger Nef, Axel Bauer, Giuseppe Mancia, Michael Böhm, Felix Mahfoud

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Renal denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. Increased 24-h BP variability is associated with adverse cardiovascular outcomes and related to sympathetic activation. Methods and results: This multicenter study investigated the effect of RDN on BP variability in 84 patients with uncontrolled hypertension (office systolic BP-140 mmHg) despite treatment with greater than three antihypertensive agents. BP variability was assessed by means of standard deviation, coefficient of variation (standard deviation/ mean), and average real variability of 24-h ambulatory SBP at 3-month and 6-month follow-up. RDN significantly reduced office BP by 17/6 mmHg at 3-month and 19/7 mmHg at 6-month follow-up (P

Original languageEnglish
Pages (from-to)2512-2518
Number of pages7
JournalJournal of Hypertension
Volume33
Issue number12
DOIs
Publication statusPublished - 2015

Keywords

  • blood pressure variability
  • renal denervation
  • resistant hypertension
  • sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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