Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension

Sebastian Ewen, Oliver Dörr, Christian Ukena, Dominik Linz, Bodo Cremers, Ulrich Laufs, Christian Hamm, Holger Nef, Axel Bauer, Giuseppe Mancia, Michael Böhm, Felix Mahfoud

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Renal denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. Increased 24-h BP variability is associated with adverse cardiovascular outcomes and related to sympathetic activation. Methods and results: This multicenter study investigated the effect of RDN on BP variability in 84 patients with uncontrolled hypertension (office systolic BP-140 mmHg) despite treatment with greater than three antihypertensive agents. BP variability was assessed by means of standard deviation, coefficient of variation (standard deviation/ mean), and average real variability of 24-h ambulatory SBP at 3-month and 6-month follow-up. RDN significantly reduced office BP by 17/6 mmHg at 3-month and 19/7 mmHg at 6-month follow-up (P

Original languageEnglish
Pages (from-to)2512-2518
Number of pages7
JournalJournal of Hypertension
Volume33
Issue number12
DOIs
Publication statusPublished - 2015

Fingerprint

Sympathectomy
Catheters
Blood Pressure
Hypertension
Kidney
Denervation
Antihypertensive Agents
Multicenter Studies

Keywords

  • blood pressure variability
  • renal denervation
  • resistant hypertension
  • sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension. / Ewen, Sebastian; Dörr, Oliver; Ukena, Christian; Linz, Dominik; Cremers, Bodo; Laufs, Ulrich; Hamm, Christian; Nef, Holger; Bauer, Axel; Mancia, Giuseppe; Böhm, Michael; Mahfoud, Felix.

In: Journal of Hypertension, Vol. 33, No. 12, 2015, p. 2512-2518.

Research output: Contribution to journalArticle

Ewen, S, Dörr, O, Ukena, C, Linz, D, Cremers, B, Laufs, U, Hamm, C, Nef, H, Bauer, A, Mancia, G, Böhm, M & Mahfoud, F 2015, 'Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension', Journal of Hypertension, vol. 33, no. 12, pp. 2512-2518. https://doi.org/10.1097/HJH.0000000000000751
Ewen, Sebastian ; Dörr, Oliver ; Ukena, Christian ; Linz, Dominik ; Cremers, Bodo ; Laufs, Ulrich ; Hamm, Christian ; Nef, Holger ; Bauer, Axel ; Mancia, Giuseppe ; Böhm, Michael ; Mahfoud, Felix. / Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension. In: Journal of Hypertension. 2015 ; Vol. 33, No. 12. pp. 2512-2518.
@article{c67526eeae5c44c19cb8f1c8b246fdd1,
title = "Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension",
abstract = "Background: Renal denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. Increased 24-h BP variability is associated with adverse cardiovascular outcomes and related to sympathetic activation. Methods and results: This multicenter study investigated the effect of RDN on BP variability in 84 patients with uncontrolled hypertension (office systolic BP-140 mmHg) despite treatment with greater than three antihypertensive agents. BP variability was assessed by means of standard deviation, coefficient of variation (standard deviation/ mean), and average real variability of 24-h ambulatory SBP at 3-month and 6-month follow-up. RDN significantly reduced office BP by 17/6 mmHg at 3-month and 19/7 mmHg at 6-month follow-up (P",
keywords = "blood pressure variability, renal denervation, resistant hypertension, sympathetic nervous system",
author = "Sebastian Ewen and Oliver D{\"o}rr and Christian Ukena and Dominik Linz and Bodo Cremers and Ulrich Laufs and Christian Hamm and Holger Nef and Axel Bauer and Giuseppe Mancia and Michael B{\"o}hm and Felix Mahfoud",
year = "2015",
doi = "10.1097/HJH.0000000000000751",
language = "English",
volume = "33",
pages = "2512--2518",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension

AU - Ewen, Sebastian

AU - Dörr, Oliver

AU - Ukena, Christian

AU - Linz, Dominik

AU - Cremers, Bodo

AU - Laufs, Ulrich

AU - Hamm, Christian

AU - Nef, Holger

AU - Bauer, Axel

AU - Mancia, Giuseppe

AU - Böhm, Michael

AU - Mahfoud, Felix

PY - 2015

Y1 - 2015

N2 - Background: Renal denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. Increased 24-h BP variability is associated with adverse cardiovascular outcomes and related to sympathetic activation. Methods and results: This multicenter study investigated the effect of RDN on BP variability in 84 patients with uncontrolled hypertension (office systolic BP-140 mmHg) despite treatment with greater than three antihypertensive agents. BP variability was assessed by means of standard deviation, coefficient of variation (standard deviation/ mean), and average real variability of 24-h ambulatory SBP at 3-month and 6-month follow-up. RDN significantly reduced office BP by 17/6 mmHg at 3-month and 19/7 mmHg at 6-month follow-up (P

AB - Background: Renal denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. Increased 24-h BP variability is associated with adverse cardiovascular outcomes and related to sympathetic activation. Methods and results: This multicenter study investigated the effect of RDN on BP variability in 84 patients with uncontrolled hypertension (office systolic BP-140 mmHg) despite treatment with greater than three antihypertensive agents. BP variability was assessed by means of standard deviation, coefficient of variation (standard deviation/ mean), and average real variability of 24-h ambulatory SBP at 3-month and 6-month follow-up. RDN significantly reduced office BP by 17/6 mmHg at 3-month and 19/7 mmHg at 6-month follow-up (P

KW - blood pressure variability

KW - renal denervation

KW - resistant hypertension

KW - sympathetic nervous system

UR - http://www.scopus.com/inward/record.url?scp=84947023459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947023459&partnerID=8YFLogxK

U2 - 10.1097/HJH.0000000000000751

DO - 10.1097/HJH.0000000000000751

M3 - Article

VL - 33

SP - 2512

EP - 2518

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 12

ER -