Blood pressure variability as a risk factor

Gianfranco Parati, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Blood pressure variability is clinically relevant because of the evidence that the degree of blood pressure fluctuation may independently contribute to organ damage and to the cardiovascular risk of hypertensive patients. This review will focus on the evidence available to support this concept. As such, data obtained from cross-sectional studies, longitudinal studies in humans and experimental studies in animals will be discussed. The possibility of antagonizing an excessive degree of blood pressure variability by administering drugs to provide a long-lasting and smooth antihypertensive action will also be discussed, as will the usefulness of mathematical indices aimed at quantifying the homogeneity of the blood pressure reduction by treatment.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalBlood Pressure Monitoring
Issue number6
Publication statusPublished - 2001


  • Ambulatory blood pressure monitoring
  • Blood pressure variability
  • Essential hypertension
  • Organ damage
  • Smoothness index

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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