Blood pressure variability, cardiovascular risk and antihypertensive treatment

Gianfranco Parati, Luisa Ulian, Cinzia Santucciu, Stefano Omboni, Giuseppe Mancia

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Twenty-four hour blood pressure parameters: The use of ambulatory blood pressure monitoring techniques has shown clearly that 24-h average blood pressure is more closely related to the end-organ damage of hypertension than isolated office blood pressure readings. It has also provided evidence that the degree of blood pressure variability over a 24-h period may be independently related to the cardiovascular complications of hypertension. However, all the available data on this issue come from cross-sectional studies, and prospective evidence on the actual prognostic value of 24-h blood pressure parameters has only recently been provided for daytime blood pressure variability. There is still no prospective evidence concerning overall 24-h blood pressure variability. Antihypertensive agents and blood pressure variability: Available antihypertensive agents are unable to effectively buffer blood pressure variability. However, drugs with a long-lasting antihypertensive effect and an optimal trough: peak ratio may at least prevent further iatrogenic increases in the amplitude of blood pressure fluctuations. Beat-to-beat blood pressure monitoring: The ability of antihypertensive agents to actually reduce 24-h blood pressure variability needs to be demonstrated in future studies, using beat-to-beat blood pressure monitoring which is now possible by means of non-invasive techniques.

Original languageEnglish
Pages (from-to)S27-S34
JournalJournal of Hypertension
Volume13
Publication statusPublished - 1995

Fingerprint

Antihypertensive Agents
Blood Pressure
Hypertension
Ambulatory Blood Pressure Monitoring
Reading
Buffers
Cross-Sectional Studies

Keywords

  • 24-h blood pressure profiles
  • Ambulatory blood pressure monitoring
  • Antihypertensive treatment
  • Blood pressure variability
  • End-organ damage
  • Hypertension
  • Trough-to-peak ratio

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Parati, G., Ulian, L., Santucciu, C., Omboni, S., & Mancia, G. (1995). Blood pressure variability, cardiovascular risk and antihypertensive treatment. Journal of Hypertension, 13, S27-S34.

Blood pressure variability, cardiovascular risk and antihypertensive treatment. / Parati, Gianfranco; Ulian, Luisa; Santucciu, Cinzia; Omboni, Stefano; Mancia, Giuseppe.

In: Journal of Hypertension, Vol. 13, 1995, p. S27-S34.

Research output: Contribution to journalArticle

Parati, G, Ulian, L, Santucciu, C, Omboni, S & Mancia, G 1995, 'Blood pressure variability, cardiovascular risk and antihypertensive treatment', Journal of Hypertension, vol. 13, pp. S27-S34.
Parati, Gianfranco ; Ulian, Luisa ; Santucciu, Cinzia ; Omboni, Stefano ; Mancia, Giuseppe. / Blood pressure variability, cardiovascular risk and antihypertensive treatment. In: Journal of Hypertension. 1995 ; Vol. 13. pp. S27-S34.
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