Abstract
Studies have shown that the circadian blood pressure profile is similar in normotensive and hypertensive subjects, and that the observed increase in blood pressure variability in hypertensive patients is proportional to the increase over the normotensive baseline blood pressure, suggesting that transient blood pressure oscillations on a percentage basis are not altered by hypertension. It has also been found that although antihypertensive therapy tends to reduce mean arterial blood pressure (MAP), the tendency to oscillate around a mean pressure is modified to a lesser extent. The significance of this observation is unknown; however, this effect should possibly be considered and studied in view of the incomplete protection against cardiovascular complications that is afforded by the current management of hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | S1-S6 |
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 16 |
| Publication status | Published - 1990 |
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Keywords
- Antihypertensive treatment
- Blood pressure, circadian rhythms
- Blood pressure, variability
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology
Cite this
Blood pressure variability : Mechanisms and clinical significance. / Mancia, G.
In: Journal of Cardiovascular Pharmacology, Vol. 16, 1990, p. S1-S6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blood pressure variability
T2 - Mechanisms and clinical significance
AU - Mancia, G.
PY - 1990
Y1 - 1990
N2 - Studies have shown that the circadian blood pressure profile is similar in normotensive and hypertensive subjects, and that the observed increase in blood pressure variability in hypertensive patients is proportional to the increase over the normotensive baseline blood pressure, suggesting that transient blood pressure oscillations on a percentage basis are not altered by hypertension. It has also been found that although antihypertensive therapy tends to reduce mean arterial blood pressure (MAP), the tendency to oscillate around a mean pressure is modified to a lesser extent. The significance of this observation is unknown; however, this effect should possibly be considered and studied in view of the incomplete protection against cardiovascular complications that is afforded by the current management of hypertension.
AB - Studies have shown that the circadian blood pressure profile is similar in normotensive and hypertensive subjects, and that the observed increase in blood pressure variability in hypertensive patients is proportional to the increase over the normotensive baseline blood pressure, suggesting that transient blood pressure oscillations on a percentage basis are not altered by hypertension. It has also been found that although antihypertensive therapy tends to reduce mean arterial blood pressure (MAP), the tendency to oscillate around a mean pressure is modified to a lesser extent. The significance of this observation is unknown; however, this effect should possibly be considered and studied in view of the incomplete protection against cardiovascular complications that is afforded by the current management of hypertension.
KW - Antihypertensive treatment
KW - Blood pressure, circadian rhythms
KW - Blood pressure, variability
UR - http://www.scopus.com/inward/record.url?scp=0025649234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025649234&partnerID=8YFLogxK
M3 - Article
C2 - 1707108
AN - SCOPUS:0025649234
VL - 16
SP - S1-S6
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
ER -