TY - JOUR
T1 - Blood thiamine, zinc, selenium, lead and oxidative stress in a population of male and female alcoholics
T2 - Clinical evidence and gender differences
AU - Mancinelli, Rosanna
AU - Barlocci, Eleonora
AU - Ciprotti, Maria
AU - Senofonte, Oreste
AU - Fidente, Rosanna Maria
AU - Draisci, Rosa
AU - Attilia, Maria Luisa
AU - Vitali, Mario
AU - Fiore, Marco
AU - Ceccanti, Mauro
PY - 2013
Y1 - 2013
N2 - Introduction: Long term alcohol abuse is associated with deficiencies in essential nutrients and minerals that can cause a variety of medical consequences including accumulation of toxic metals. Aim. The aim of this research is to get evidence-based data to evaluate alcohol damage and to optimize treatment. Thiamine and thiamine diphosphate (T/TDP), zinc (Zn), selenium (Se), lead (Pb) and oxidative stress in terms of reactive oxygen metabolites (ROMs) were examined in blood samples from 58 alcohol dependent patients (17 females and 41 males). Results: T/TDP concentration in alcoholics resulted significantly lower than controls (p <0.005) for both sexes. Serum Zn and Se did not signifcantly differ from reference values. Levels of blood Pb in alcoholics resulted signifcantly higher (p <0.0001) than Italian reference values and were higher in females than in males. ROMs concentration was significantly higher than healthy population only in female abusers (p = 0.005). Conclusion: Alcoholics show a significant increase in blood oxidative stress and Pb and decrease in thiamine. Impairment occurs mainly in female abusers confirming a gender specific vulnerability.
AB - Introduction: Long term alcohol abuse is associated with deficiencies in essential nutrients and minerals that can cause a variety of medical consequences including accumulation of toxic metals. Aim. The aim of this research is to get evidence-based data to evaluate alcohol damage and to optimize treatment. Thiamine and thiamine diphosphate (T/TDP), zinc (Zn), selenium (Se), lead (Pb) and oxidative stress in terms of reactive oxygen metabolites (ROMs) were examined in blood samples from 58 alcohol dependent patients (17 females and 41 males). Results: T/TDP concentration in alcoholics resulted significantly lower than controls (p <0.005) for both sexes. Serum Zn and Se did not signifcantly differ from reference values. Levels of blood Pb in alcoholics resulted signifcantly higher (p <0.0001) than Italian reference values and were higher in females than in males. ROMs concentration was significantly higher than healthy population only in female abusers (p = 0.005). Conclusion: Alcoholics show a significant increase in blood oxidative stress and Pb and decrease in thiamine. Impairment occurs mainly in female abusers confirming a gender specific vulnerability.
KW - Alcohol abuse
KW - Essential nutrients
KW - Gender differences
KW - Oxidative strss
KW - Pb accumulation
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U2 - 10.4415/ANN-13-01-11
DO - 10.4415/ANN-13-01-11
M3 - Article
C2 - 23535132
AN - SCOPUS:84875500357
VL - 49
SP - 65
EP - 72
JO - Annali dell'Istituto Superiore di Sanita
JF - Annali dell'Istituto Superiore di Sanita
SN - 0021-2571
IS - 1
ER -