Abstract
The possibility of ameliorating bone healing of implanted bone allografts is a field of great interest. Early vascular invasion is a key factor in bone allograft incorporation. It is well known that copper ions (Cu 2+) show a proangiogenic action favouring the development of new vessels. In this work a hyaluronan based 50% hydrogel (Hyal-50%) was enriched with (Cu 2+) and its proangiogenic activity was evaluated. Fifteen Sprague Dawley female rats were submitted to the subcutaneous implantation of Hyal-50%, freeze-dried bone allografts, Hyal-50%-Cu 2+, freeze-dried bone allografts plus Hyal-50% and freeze-dried bone allografts plus Hyal-50%-Cu 2+. One month later, histomorphometric analysis evidenced the presence of a fibrous-reactive capsule around all specimens showing significant differences among groups (p2+ plus freeze-dried bone (15.2%, p2+. Statistical analysis showed a significant (p2+ and Hyal-50%-Cu 2+ plus freeze-dried bone group when compared to other groups. The present preliminary results suggest the advantages offered by the combined use of a well-known biocompatible and tissue healing promoting material (Hyal-50%) and a new technique that consists of stimulating tissue vascularization using Cu 2+ and that bone allograft incorporation may benefit from this technology.
Original language | English |
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Pages (from-to) | 3001-3008 |
Number of pages | 8 |
Journal | Biomaterials |
Volume | 26 |
Issue number | 16 |
DOIs | |
Publication status | Published - Jun 2005 |
Keywords
- Copper ions
- Freeze-dried bone allograft
- Hyaluronan
- Hydrogel
- Soft-tissue implants
- Vessel formation
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering